Novel Anti-Aging Benzoquinone Derivatives from Wall.

The aim of this study was to investigate anti-aging molecules from Wall, a traditional medicinal plant used in the Unani and Ayurvedic systems of medicine. During bioassay-guided isolation, two known benzoquinones, allomicrophyllone () and ehretiquinone () along with three novel benzoquinones designated as ehretiquinones B-D (-) were isolated from . Their structures were characterized by spectroscopic analysis through 1D and 2D NMR, by MS spectroscopic analysis and comparing with those reported in the literatures. The anti-aging potential of the isolated benzoquinones was evaluated through a yeast lifespan assay, and the results indicated that , , and significantly extended the replicative lifespan of K6001 yeast, indicating that these benzoquinones obtained from have the ability to be employed as a potential therapeutic agent against age-related diseases.