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| http://dx.doi.org/10.1111/plb.12984 | DOI Listing |
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Design principles for engineering bacteria to maximise chemical production from batch cultures.
Nat Commun
January 2025
Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, UK.
Bacteria can be engineered to manufacture chemicals, but it is unclear how to optimally engineer a single cell to maximise production performance from batch cultures. Moreover, the performance of engineered production pathways is affected by competition for the host's native resources. Here, using a 'host-aware' computational framework which captures competition for both metabolic and gene expression resources, we uncover design principles for engineering the expression of host and production enzymes at the cell level which maximise volumetric productivity and yield from batch cultures.
View Article and Find Full Text PDFMoving Beyond Oxford Nanopore Standard Procedures: New Insights from Water and Multiple Fish Microbiomes.
Int J Mol Sci
November 2024
Nutrigenomics and Fish Growth Endocrinology Group, Instituto de Acuicultura Torre de la Sal (IATS, CSIC), 12595 Ribera de Cabanes, Castellón, Spain.
Oxford Nanopore Technology (ONT) allows for the rapid profiling of aquaculture microbiomes. However, not all the experimental and downstream methodological possibilities have been benchmarked. Here, we aimed to offer novel insights into the use of different library preparation methods (standard-RAP and native barcoding-LIG), primers (V3-V4, V1-V3, and V1-V9), and basecalling models (fast-FAST, high-HAC, and super-accuracy-SUP) implemented in ONT to elucidate the microbiota associated with the aquatic environment and farmed fish, including faeces, skin, and intestinal mucus.
View Article and Find Full Text PDFOptimising Control Device Luring Strategies for Invasive Predator Control: A Modelling Approach.
Ecol Evol
December 2024
Manaaki Whenua - Landcare Research Lincoln New Zealand.
Invasive predators pose a serious threat to native biodiversity, with trapping being one of several methods developed to manage and monitor their populations. Many individuals in these predator populations have been found to display trap-shyness, which hinders eradication and results in inaccurate estimates of population size. Lures are used to help overcome trap-shyness by increasing the probability of interaction with the device, but the extent of trap-shyness in wild populations, and the best timing for the introduction of a new lure or combination of lures, are uncertain.
View Article and Find Full Text PDFWild-Type Domestication: Loss of Intrinsic Metabolic Traits Concealed by Culture in Rich Media.
Microb Ecol
November 2024
Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Bacteria are typically isolated on rich media to maximise isolation success, removing them from their native evolutionary context. This eliminates selection pressures, enabling otherwise deleterious genomic events to accumulate. Here, we present a cautionary tale of these 'quiet mutations' which can persist unnoticed in bacterial culture lines.
View Article and Find Full Text PDFThe 2024 report of the Lancet Countdown on health and climate change: facing record-breaking threats from delayed action.
Lancet
November 2024
Institute for Global Health, University College London, London, UK.
Article Synopsis
- The world is nearing the critical threshold of 1.5°C warming, with 2023 recording an average temperature rise of 1.45°C since pre-industrial times, leading to severe climate-related impacts.
- The Countdown collaboration, formed to assess the health impacts of climate change post-Paris Agreement, involves over 300 experts analyzing data and trends annually.
- The 2024 report highlights troubling increases in climate-related health risks, such as a staggering 167% rise in heat-related deaths among seniors, indicating worsening conditions affecting wellbeing globally.
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