Studies have shown that diesel exhaust particles (DEP) induced oxidative stress and inflammation. This present study examined the molecular effects of aqueous rooibos extract (RE) on the cardiovascular toxic effect of methanol extract of DEP in exposed Wistar rats. The results showed that DEP caused significant (p < 0.001) increase in MDA and CDs levels in the aorta and heart but this increase was significantly (p < 0.001) attenuated by rooibos extract. DEP induced IL-8, TNFα, IL-1β and decreased IL-10 gene expressions, all of which were reversed in the presence of rooibos extract. The expression of NF-κB, and IκKB genes were also significantly (p < 0.001) induced by DEP in both tissues, but pre-treatment with RE attenuated these effects. In contrast, DEP repressed IκB mRNA level, which was significantly (p < 0.001) reversed by rooibos extract pre-treatment. In addition, pre-treatment with rooibos extract attenuated the increased Nrf2 and HO-1 mRNA levels caused by DEP. This indicates the potential of rooibos extract to protect against DEP-induced cardiovascular toxicity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441828 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2019.e01426 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of antidiabetic and anti-inflammatory action of selenium nanoparticles mediated through aspalathus linearis - An in vitro study.
Med J Malaysia
January 2025
Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, India.
Introduction: Selenium nanoparticles (SeNPs) have drawn a lot of interest among researchers because of their distinct impact on antioxidant activity, anti-inflammatory tests, antibacterial activity, and in the treatment of various diseases. A. linearis has shown great findings in biomedical applications because of its physio-chemical compounds such as Aspalathin, orientin, and isoorientin.
View Article and Find Full Text PDFAnti-diabetic and anti-microbial activity of aspalathus linearis and syzygium aromaticum formulation mediated zinc oxide nanoparticles.
Med J Malaysia
January 2025
Nanobiomedicine lab, Centre for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamilnadu, India.
Introduction: Zinc oxide nanoparticles (ZnO NPs) exhibit a wide range of biomedical applications majorly used as antiinflammatory, anti-cancer, anti-diabetic, and anti-microbial activity and other biomedical applications because they show less toxicity and are very compatible. Zinc metal is an inorganic and essential element in the human body at the trace level. ZnO NPs are also GRAS substances (Generally Recognized As Safe).
View Article and Find Full Text PDFThe Neuroprotective Effect of Rooibos Herbal Tea Against Alzheimer's Disease: A Review.
Mol Nutr Food Res
January 2025
Applied Microbial and Health Biotechnology Institute, Cape Peninsula University of Technology, Cape Town, South Africa.
The world is experiencing a demographic shift toward an increasing proportion of elderly persons. Alzheimer's disease (AD) and other neurological disorders are far more likely to develop as people age. AD is a gradual, irreversible, and degenerative brain disorder that progressively deteriorates memory and cognitive function, eventually leading to death.
View Article and Find Full Text PDFMulti-targeted action of rooibos may protect against ischaemic stroke-induced neurological deficit and endothelial dysfunction.
J Ethnopharmacol
January 2025
Experimental Medicine Research Group, Division of Internal Medicine, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa. Electronic address:
Ethnopharmacological Relevance: Indigenous use communities in the Western Cape (South Africa) where Aspalathus linearis (Brum.f) R.Dahlgren - or rooibos - grows naturally, has a long history of using rooibos for medicinal purposes.
View Article and Find Full Text PDFImpact of Chronic Consumption of Herbal Rooibos on Cardiovascular Function in Adults with Cardiovascular Risk.
J Med Food
October 2024
Center for Postgraduate Studies, Cape Peninsula University of Technology, Cape Town, South Africa.
The prevalence of cardiovascular disease (CVD) has increased in South Africa, emphasizing the importance of prevention strategies. This study used echocardiography to investigate the impact of Rooibos on cardiovascular function in those at risk of CVD. This research aims to contribute to understanding its effects on reducing cardiovascular risk factors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!