AI Article Synopsis
- - A new method for nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform has been created, featuring a micro-flow process.
- - This technique successfully transforms -sulfinylimines into trifluoromethyl amines with high diastereoselectivity.
- - The application of this micro-flow synthesis is showcased through the formal synthesis of the drug Efavirenz.
Article Abstract
A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of -sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442697 | PMC |
| http://dx.doi.org/10.1002/open.201800286 | DOI Listing |
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