AI Article Synopsis
- Seven resorcylic acid lactones (RALs) were isolated from an endophytic fungus found in a plant from the Tengger Desert in China, including five new analogs named rhinoclactones A-E.
- The structures of these new compounds were confirmed using advanced techniques such as high-resolution mass spectrometry, NMR, and X-ray diffraction, revealing a unique chemical feature not commonly seen in nature.
- One of the compounds exhibited cytotoxic effects on human cancer cell lines, and the study discusses its potential biosynthesis and the ecological roles of these metabolites.
Article Abstract
Seven resorcylic acid lactones (RALs) including five new analog rhinoclactones, A-E (, , -), were isolated from an endophytic fungus in the plant collected from the Tengger Desert of the Ningxia Province, China. The structures of these new compounds were determined by HR-ESI-MS (High Resolution Electrospray Ionization Mass Spectrometry), NMR data, modified Mosher's method, and X-ray diffraction experiments. All compounds isolated from this fungus possessed the 16-OMe/14-OH, not the common 16-OH/14-OH or 16-OH/14-OMe groups on the aromatic ring, which are rarely found in nature. Compound displayed cytotoxic activities against HCT116 and HeLa cancer cell lines. The possible biosynthesis of - is suggested, and the potential ecological roles of these fungal secondary metabolites is discussed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480478 | PMC |
| http://dx.doi.org/10.3390/molecules24071405 | DOI Listing |
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Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus .
Molecules
April 2019
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Article Synopsis
- Seven resorcylic acid lactones (RALs) were isolated from an endophytic fungus found in a plant from the Tengger Desert in China, including five new analogs named rhinoclactones A-E.
- The structures of these new compounds were confirmed using advanced techniques such as high-resolution mass spectrometry, NMR, and X-ray diffraction, revealing a unique chemical feature not commonly seen in nature.
- One of the compounds exhibited cytotoxic effects on human cancer cell lines, and the study discusses its potential biosynthesis and the ecological roles of these metabolites.
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