[This corrects the article DOI: 10.1371/journal.pone.0212989.].
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459474 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215491 | PLOS |
Transplant Cell Ther
May 2024
Division of Hematology/Oncology, Blood and Marrow Transplant/Cellular Therapy, Hospital for Sick Children, Toronto, Ontario, Canada.
Inborn errors of immunity (IEI) are often associated with inflammatory bowel disease (IBD). IEI can be corrected by allogeneic hematopoietic stem cell transplantation (HSCT); however, peritransplantation intestinal inflammation may increase the risk of gut graft-versus-host disease (GVHD). Vedolizumab inhibits the homing of lymphocytes to the intestine and may attenuate gut GVHD, yet its role in preventing GVHD in pediatric patients with IEI-associated IBD has not been studied.
View Article and Find Full Text PDFJ Crohns Colitis
August 2024
Child Health Innovation Leadership Department, Johnson & Johnson, New Brunswick, NJ, USA.
Inflamm Bowel Dis
September 2024
Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Background: Biologic medications are a common therapy for those with inflammatory bowel disease (IBD). There are limited data on the outcomes of home-based biologic infusions for patients with IBD. The aim of this study was to compare the safety and efficacy of biologic infusions for IBD patients who receive either home- or office-based administration.
View Article and Find Full Text PDFInflamm Bowel Dis
May 2024
Clinic of General Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Background: The aim of this observational, real-world evidence, modified intention-to-treat (mITT) study based on prospectively collected data from the VEDOIBD registry was to compare the effectiveness of vedolizumab (VEDO) vs antitumor necrosis factor (anti-TNF) in biologic-naïve Crohn's disease (CD) patients.
Methods: Between 2017 and 2020, 557 CD patients starting therapy with VEDO or anti-TNF were consecutively enrolled in 45 IBD centers across Germany. Per study protocol, the analysis excluded biologic-experienced patients and those with a missing Harvey-Bradshaw Index score, resulting in a final sample of 327 biologic-naïve CD patients.
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