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| http://dx.doi.org/10.4103/aca.ACA_89_18 | DOI Listing |
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A non-interpenetrated mesoporous hydrogen-bonded organic framework constructed with 1,3,5-tri(4-carboxyphenyl)benzene.
Chem Commun (Camb)
January 2025
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, P. R. China.
The discovery of porous molecular solids has been constantly hindered by phase transformation and interpenetration. Here, we crystallize two molecules with three substituted carboxylic groups. A mesoporous, non-interpenetrated HOF that is constructed from 1,3,5-tri(4-carboxyphenyl)benzene (TCPB) is discovered and reported for the first time.
View Article and Find Full Text PDFDiscovery and Synthetic Applications of a NAD(P)H-Dependent Reductive Aminase from .
ACS Catal
January 2025
Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Reductive amination is one of the most synthetically direct routes to access chiral amines. Several Imine Reductases (IREDs) have been discovered to catalyze reductive amination (Reductive Aminases or RedAms), yet they are dependent on the expensive phosphorylated nicotinamide adenine dinucleotide cofactor NADPH and usually more active at basic pH. Here, we describe the discovery and synthetic potential of an IRED from (RedAm) that catalyzes reductive amination between a series of medium to large carbonyl and amine compounds with conversions of up to >99% and 99% enantiomeric excess at neutral pH.
View Article and Find Full Text PDFStructure-Guided Discovery of Novel -(Substituted Thiazol-2-yl)--(4-Substituted phenyl)pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability.
J Med Chem
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Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, P. R. China.
CDK2 and CDK9 play pivotal roles in cell cycle progression and gene transcription, respectively, making them promising targets for cancer treatment. Herein, we discovered a series of -(substituted thiazol-2-yl)--(4-substituted phenyl)pyrimidine-2,4-diamines as highly potent CDK2/9 dual inhibitors. Especially, compound significantly inhibited CDK2 (IC = 0.
View Article and Find Full Text PDFNovel Variant of New Delhi Metallo-Beta-Lactamase () Discovered in a Clinical Strain of from the United Arab Emirates: An Emerging Challenge in Antimicrobial Resistance.
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Tawam Hospital, Al Ain P.O. Box 5674, United Arab Emirates.
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View Article and Find Full Text PDFJunctional Role of Anionic Domain of Mussel Foot Protein Type 4 in Underwater Mussel Adhesion.
Biomacromolecules
January 2025
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
Mussel byssi form a robust underwater adhesive system, anchoring to various surfaces in harsh marine environments. Central to byssus is foot protein type 4 (fp-4), a junction protein connecting collagenous threads to proteinaceous plaque. This study investigated an anionic plaque-binding domain of fp-4 (fp-4a) and its interactions with cationic foot proteins (fp-1, fp-5, and fp-151 as model substitutes for fp-2) and metal ions (Ca, Fe, and V).
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