Focal nodular hyperplasia (FNH) is a benign non-neoplastic lesion of the liver usually found in adults. It is uncommon in children, comprising 2-10% of all pediatric liver tumours. In children, it can occur at all ages, with increased frequency between 6-10 years. We present two cases of FNH in childhood- the first being that of a 5-month-old infant, and the second in a 6-year-old boy. The possibility of congenital FNH had been excluded in the first case. The second case posed diagnostic difficulty initially and was wrongly treated for hepatoblastoma by neoadjuvant chemotherapy, but later correctly diagnosed to be FNH. Both the children are doing well on follow-up. Paediatric FNH though rare, should be kept in mind while dealing with a hepatic mass. Radiological features can be variable and needle sampling may not be sufficient to reach to a diagnosis. Histological examination with glutamine synthetase immunostaining should be performed in doubtful cases to differentiate FNH from other paediatric liver masses, as management differs.
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http://dx.doi.org/10.4103/IJPM.IJPM_396_18 | DOI Listing |
Cardiovasc Intervent Radiol
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Ytrrium-90 Precision Interventional Radiotherapy Center of Liver Cancer, SchoolofClinicalMedicine, Beijing Tsinghua Changgung Hospital, TsinghuaUniversity, Beijing, China.
Neuro Oncol
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Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institut für Neuropathologie, Charitéplatz 1, 10117 Berlin, Germany.
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Histopathology, Jordanian Royal Medical Services, Amman, JOR.
Osteosarcoma (OS) is a rare form of malignant bone tumor affecting jaws. The diagnosis of jaws osteosarcoma (JO) presents a unique challenge due to its rarity and the diversity of histological presentations it can exhibit. Fibroblastic osteosarcoma (FO), a subtype of OS, is characterized by the presence of fibroblastic cells and osteoid-producing cells within the tumor matrix.
View Article and Find Full Text PDFQuant Imaging Med Surg
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Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Background: Liver hemangiomas (HGs) are characterized by cavernous venous spaces delineated by a lining of vascular endothelial cells and interspersed with connective tissue septa. Typically, a liver HG has higher apparent diffusion coefficient (ADC) and T2 values than those of hepatocellular carcinomas (HCCs) and liver metastases, and lower ADC and T2 values than those of liver simple cysts. However, a portion of HGs shows ADC and T2 overlapping with those of HCC, liver metastasis, and simple cyst.
View Article and Find Full Text PDFQuant Imaging Med Surg
December 2024
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Focal nodular hyperplasia (FNH) in the liver is a benign lesion and the relationship between lesion size and imaging features is yet to be established. We aimed to develop and validate a scoring system to assess the relationship between magnetic resonance imaging (MRI) features and lesion size in FNH.
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