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Dipeptidyl peptidase-4 inhibitor linagliptin reduces inflammatory response, ameliorates tissue edema formation, and improves survival in severe sepsis.
Biomed Pharmacother
December 2024
Department of Research, Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address:
Background: Excessive inflammation in sepsis causes microvascular dysfunction associated with organ dysfunction and high mortality. The present studies aimed to examine the therapeutic potential of linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in a clinically relevant polymicrobial sepsis model in mice.
Methods: Sepsis was induced by cecal ligation and puncture (CLP).
Lack of progress in cancer related outcomes after Liver Transplantation: Mitigating risk & identifying future needs to move this needle.
Liver Transpl
October 2024
Department of Internal Medicine, Mayo Clinic, Rochester MN.
Malignancy has a crucial impact on long-term survival after liver transplantation. There has been enhanced early detection rates with refined cancer screening and improved prognosis for many cancer diagnoses in the general population with the advent of targetted anti-cancer therapies. Similar advancements have not occurred in the transplant population over this same timeframe.
View Article and Find Full Text PDFMOLDOVA - SYSTEMATIC PREPAREDNESS FOR MEDICAL RESPONSE TO RADIATION EMERGENCIES.
Probl Radiac Med Radiobiol
December 2024
State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Under the conditions of a full-scale russian invasion of Ukraine, the danger of the development of radiation and nuclear emergency situations in the region has increased significantly. An external independent assessment of the ability of health care system of the Republic of Moldova to respond to emergency situations revealed the need to develop a training program for medical workers on the basics of responding to radiation and nuclear threats. In addition, the evaluation recommended the development of a standard for victims care taking into account the existing evidence base.
View Article and Find Full Text PDFIMPLEMENTATION OF THE EDUCATIONAL MODULE «MANAGING EXPOSURE ASSESSMENT AND MEDICAL RESPONSE TO A RADIATION EMERGENCY IN UKRAINE».
Probl Radiac Med Radiobiol
December 2024
The WHO Country Office in Ukraine (WHO CO), Kyiv, Ukraine.
The WHO educational module УДК «Ma naging exposure assessment and medical response to a radiation emergency in Ukraine» was developed and implemented. In total, 25 trainings were conducted for 377 healthcare professionals from 6 regions of Ukraine during 2023-2024.
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