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| http://dx.doi.org/10.1177/1076029619841701 | DOI Listing |
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New data on FII, FV, FIX and thrombomodulin defects: blood keeps clotting in normal and in peculiar ways.
Hematology
December 2019
Department of Medicine, University of Padua Medical School, Padua, Italy.
To present the clinical and laboratory implications of defects or variants of some clotting factors and of thrombomodulin that were discovered during the past few years.: Data concerning new aspects of FII, FV, FIX and thrombomodulin defects were investigated. This involved the dysprothrombinemias, the East Texas or short FV disorder, a FIX defect and a thrombomodulin abnormality.
View Article and Find Full Text PDFThe Dysprothrombinemias due to Arg596 Mutations: A Conundrum With No Bleeding Tendency and Venous Thrombosis due to Antithrombin Resistance.
Clin Appl Thromb Hemost
November 2019
1 Department of Medicine, University of Padua Medical School, Padua, Italy.
Vitamin K-Dependent Coagulation Factors That May be Responsible for Both Bleeding and Thrombosis (FII, FVII, and FIX).
Clin Appl Thromb Hemost
December 2018
Department of Medicine, University of Padua Medical School, Padua, Italy.
Article Synopsis
- - Vitamin K-dependent clotting factors are now recognized as playing dual roles in both promoting and preventing blood clots, challenging previous classifications of these factors as purely hemorrhagic or thrombotic disorders.
- - Recent discoveries, particularly mutations within factors IX and VII, have shown that certain genetic defects can lead to an increased risk of venous thrombosis rather than bleeding, indicating a complex interaction in coagulation.
- - Advances in molecular biology have expanded our understanding of blood coagulation, revealing that defects in proteins like prothrombin can cause clotting issues even in the absence of bleeding tendencies.
Prothrombin: Another Clotting Factor After FV That Is Involved Both in Bleeding and Thrombosis.
Clin Appl Thromb Hemost
September 2018
2 Division of Medicine, Padua City Hospital, Padua, Italy.
Clotting factor defects are usually associated with bleeding. About 2 decades ago, 2 polymorphisms, one of FII (G20210A) and another of FV (Arg506Gln), have been shown to be associated with prothrombotic state and venous thrombosis. As a consequence, FII and FV could be considered both as prohemorrhagic factors and prothrombotic conditions.
View Article and Find Full Text PDFCongenital prothrombin defects: they are not only associated with bleeding but also with thrombosis: a new classification is needed.
Hematology
March 2018
a Department of Medicine , University of Padua Medical School, Padua , Italy.
Objective: Congenital prothrombin deficiency is one of the rarest clotting disorders. It is commonly subdivided in Type I defects or cases of 'true' prothrombin deficiency characterized by a concomitant decrease in FII activity and antigen and in Type II or dysprothrombinemias, in which FII activity is low but FII antigen is normal or near normal. A bleeding tendency, often a severe one, is the hallmark of the two-defects even though the bleeding is usually less severe in the Type 2 defects or dysprothrombinemias.
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