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A case series and literature review of blastomycosis during pregnancy amidst the COVID-19 crisis.
Int J Gynaecol Obstet
November 2023
Department of Obstetrics & Gynecology, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.
Blastomycosis dermatitidis is a rare fungus known for is classic mimicry of pneumonia, lung cancer, and mycobacterial infections. Whilst it is known best for affecting those in the Ohio and Mississippi River basins, several cases have erupted in the Midwest region. Few case reports have focused on blastomycosis and its sequalae in pregnancy.
View Article and Find Full Text PDFMycobacterial Heat Shock Proteins in Sarcoidosis and Tuberculosis.
Int J Mol Sci
March 2023
Department of Pulmonology, Medical University of Gdansk, 80-210 Gdansk, Poland.
Pathological similarities between sarcoidosis (SA) and tuberculosis (TB) suggest the role of mycobacterial antigens in the etiopathogenesis of SA. The Dubaniewicz group revealed that not whole mycobacteria, but Mtb-HSP70, Mtb-HSP 65, and Mtb-HSP16 were detected in the lymph nodes, sera, and precipitated immune complexes in patients with SA and TB. In SA, the Mtb-HSP16 concentration was higher than that of Mtb-HSP70 and that of Mtb-HSP65, whereas in TB, the Mtb-HSP16 level was increased vs.
View Article and Find Full Text PDFTuberculosis of the knee masquerading as pigmented villonodular synovitis: Report of two cases.
Int J Surg Case Rep
November 2021
Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Introduction And Importance: The manifestation of tuberculous mimicry is challenging to diagnose, especially in extrapulmonary Tuberculosis (TB). Pigmented villonodular synovitis (PVNS) may mimic tuberculous arthritis of the knee joint. In young, otherwise healthy-appearing individuals, tuberculous arthritis and PVNS in the knee joint could present as monoarticular involvement, with painful swelling of extended duration and limited movement.
View Article and Find Full Text PDFTuberculosis presenting as metastatic lung cancer.
Int J Mycobacteriol
October 2021
Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Mycobacterium tuberculosis infection (TB) masquerading as lung tumor is well reported, but its mimicry as metastatic thoracic cancer is rare. We report the case of a young male who presented with clinical and radiological picture of lung cancer but investigations confirmed it as TB. A 35-year-old male, with 18-pack year of smoking history, presented with dry cough, anorexia, weight loss, and lower back and left hip pain.
View Article and Find Full Text PDFThe pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic.
Proc Natl Acad Sci U S A
March 2021
Department of Biological Chemistry, John Innes Centre, NR4 7UH Norwich, United Kingdom;
DNA gyrase, a type II topoisomerase, introduces negative supercoils into DNA using ATP hydrolysis. The highly effective gyrase-targeted drugs, fluoroquinolones (FQs), interrupt gyrase by stabilizing a DNA-cleavage complex, a transient intermediate in the supercoiling cycle, leading to double-stranded DNA breaks. MfpA, a pentapeptide-repeat protein in mycobacteria, protects gyrase from FQs, but its molecular mechanism remains unknown.
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