Machaerinic acid 3---D-glucuronopyranoside (), along with ten known compounds (-) were isolated from the methanol extract of L. aerial parts. Their structures were confirmed by 1D and 2D NMR analysis and HRESIMS. Compound was evaluated for the anti-proliferative activity against 95D and HT29 cancer cell lines and showed no cytotoxicity at the concentration of 100 µM.
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New acylated triterpenoid saponins from the roots of Acacia polyacantha Willd. (Fabaceae).
Carbohydr Res
January 2023
Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé I, BP 812, Yaoundé, Cameroon. Electronic address:
In our continuing search of saponins from the plants of Fabaceae family, phytochemical investigation of the roots of Acacia polyacantha, led to the isolation and structural characterization of six undescribed triterpenoid saponins, named polyacosides A-F (1-6). Their structures were established, using extensive analysis by NMR techniques, mainly 1D NMR (H, C, and DEPT) and 2D NMR (COSY, NOESY, HSQC, TOCSY and HMBC) experiments, HRESIMS and by comparison with the literature data, as 3-O-[β-d-xylopyranosyl-(1 → 4)- [β-d-galactopyranosyl-(1 → 2)-β-d-xylopyranosyl-(1 → 2)]-α-l-arabinopyranosyl]-21-O-[Cis-2-methoxycinnamoyl] machaerinic acid (1), 3-O-[β-d-xylopyranosyl-(1 → 4)- [β-d-galactopyranosyl-(1 → 2)-β-d-xylopyranosyl-(1 → 2)]-α-l-arabinopyranosyl]-21-O- [Cis-3,4-dimethoxycinnamoyl] machaerinic acid. (2), 3-O- [β-d-galactopyranosyl-(1 → 2)-β-d-xylopyranosyl-(1 → 2)-α-l-arabinopyranosyl]-21-O- [Trans-4-methoxycinnamoyl] machaerinic acid (3), 3-O- [β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyl] -21-O- [Cis-3,4-dimethoxycinnamoyl] machaerinic acid (4), 3-O- [β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyl] -21-O- [Cis-2-methoxycinnamoyl] machaerinic acid (5) and 3-O- [β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyl] -21-O- [Trans-4-methoxycinnamoyl] machaerinic acid (6).
View Article and Find Full Text PDFMachaerinic acid 3---D-glucuronopyranoside from .
Nat Prod Res
October 2020
Key Laboratory of Preventive Veterinary Medicine and Biotechnology, Longyan University, Longyan, P.R. China.
Machaerinic acid 3---D-glucuronopyranoside (), along with ten known compounds (-) were isolated from the methanol extract of L. aerial parts. Their structures were confirmed by 1D and 2D NMR analysis and HRESIMS.
View Article and Find Full Text PDF[Isolation and identification of chemical constituents from Albizia julibrissin Durazz].
Beijing Da Xue Xue Bao Yi Xue Ban
August 2004
Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Bejing 100083, China.
Objective: To study the chemical constituents of the stem bark of Albizia julibrissin Durazz.
Methods: Chemical constituents were isolated by the repeated chromatography methods and their structures were identified by spectral analysis.
Results: Five compounds were obtained as follows: 3-O-[beta-D-xylopyranosyl-(1-->2)-beta-D-fucopyranosyl-(1-->6)-beta-D-glucopyranosyl]-21-O-(6S)-2-trans-2-hydroxy-methyl-6-methyl-6-O-beta-D-quinovopyranosyl-2,7- octadienoyl-acacic acid-28 -O-beta-D-glucopyran -osyl(1-->3)-[alpha-L-arabinofuranosyl (1-->4)]-alpha-L-rhamnopyranosyl(1-->2)]-beta-D- glucopyranosyl ester (1).
Triterpenoid saponins and sapogenin lactones from Albizia gummifera.
Phytochemistry
April 2000
Institut für Pharmazeutische Chemie, Universität Graz, Austria.
The structures of two new monodesmosidic and bisdesmosidic triterpenoid saponins (1 and 2) and the known compound delta 5-stigmasterol-3-O-beta-D-glucopyranoside (3) as well as two new oleanane type triterpene lactone glycosides 4, 5 and a new sapogenin lactone 6 isolated from the stem bark of Albizia gummifera C.A. Smith (Mimosaceae) have been elucidated as 3-O-¿beta-D-glucopyranosyl(1-->2)-[alpha-L-arabinopyranosyl(1-->6) ]-beta-D- glucopyranosyl¿-oleanolic acid (1), beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl 3-O-¿beta-D-glucopyra-nosyl(1-->2)-[alpha-L-arabinopyrano syl(1-->6)]-beta-D- glucopyranosyl¿-oleanolate (2), 3 beta-¿O-D-glucopyranosyl-(1-->2)-[O-alpha-L-arabinopyranosyl(1-->6 )] beta-D-glucopyranosyloxy¿-machaerinic acid gamma-lactone (4), 3 beta-O-beta-D-glucopyranosiduronic acid (1-->2)-beta-D-glucopyranosyloxy]-machaerinic acid gamma-lactone (5), and A-homo-3a-oxa-5 beta-olean-12-en-3-one-28-oic acid (6), respectively.
View Article and Find Full Text PDF[Studies on the triterpene sapogenins from Albizziae Cortex].
Yao Xue Xue Bao
May 2001
Department of Phytochemistry, Beijing Medical University, Beijing, 100083.
A new sapogenin named Julibrogenin A was isolated from the stem bark of Albizzia julibrissin Durazz (Albizziae Cortex). Based on chemical and spectral studies, their structure has been identified as 21-O-(2-hydroxymethyl-6-methyl-6-methoxyl-2,7-octadienoyl)-acacic acid. In addition, machaerinic acid lactone, machaerinic acid methylester, acacigenin B and julibrotriterpenoidal lactone A were also isolated from this plant and characterised.
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