Five indole derivatives, 1-indol-7-ol (), tryptophol (), 3-indolepropionic acid (), tryptophan (), 3,3-di(1-indol-3-yl)propane-1,2-diol () and two diketopiperazines, cyclo(L-Pro-L-Tyr) (), cyclo[L-(4-hydroxyprolinyl)-L-leucine () along with one dihydrocinnamic acid () were isolated from VERA8, that endophytic bacteria derived from roots. This is a first report towards an isolation of endophytic strains (funji or bacteria) from the herb. The synergetic properties of the total extract compositions, as well as effects of the pure isolated secondary metabolites evaluated on their melanin synthesis in murine B16 cells towards for vitiligo treatment.
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| http://dx.doi.org/10.1080/14786419.2019.1597354 | DOI Listing |
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