AI Article Synopsis
- Curcumin, a key active ingredient from a traditional medicinal plant, was studied for its protective effects against liver damage in rats caused by carbon tetrachloride (CCl₄).
- The research involved creating curcumin nanoparticles (ηCur) that are less than 220 nm in size, using specific polymers for stabilization.
- Results showed that ηCur provided significantly greater liver protection compared to regular curcumin, as observed through behavioral tests, serum analysis, and liver tissue examinations.
Article Abstract
Curcumin is the major bioactive compound of , an important medicinal plant used in traditional herbal formulations since ancient times. In the present study, we report that curcumin nanoparticles (ηCur) protects Wistar rats against carbon tetrachloride (CCl₄)-induced subacute hepatotoxicity. Nanoparticles of sizes less than 220 nm with spherical shape were prepared using PLGA and PVA respectively as polymer and stabilizer. Test animals were injected via intraperitoneal route with 1 mL/kg CCl₄ (8% in olive oil) twice a week over a period of 8 weeks to induce hepatotoxicity. On the days following the CCl₄ injection, test animals were orally administered with either curcumin or its equivalent dose of ηCur. Behavioural observation, biochemical analysis of serum and histopathological examination of liver of the experimental animals indicated that ηCur offer significantly higher hepatoprotection compared to curcumin.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415407 | PMC |
| http://dx.doi.org/10.3390/polym10050541 | DOI Listing |
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