Fe₃O₄ nanoparticles were loaded into poly-l-lactide (PLLA) with concentrations of 2% and 5%, respectively, using an electrospinning method. In vivo animal experiments were then performed to evaluate the potential of the Fe₃O₄/PLLA nanofibrous material for bone tissue engineering applications. Bony defects with a diameter of 4 mm were prepared in rabbit tibias. Fe₃O₄/PLLA nanofibers were grafted into the drilled defects and histological examination and computed tomography (CT) image detection were performed after an eight-week healing period. The histological results showed that the artificial bony defects grafted with Fe₃O₄/PLLA nanofibers exhibited a visibly higher bone healing activity than those grafted with neat PLLA. In addition, the quantitative results from CT images revealed that the bony defects grafted with 2% and 5% Fe₃O₄/PLLA nanofibers, respectively, showed 1.9- and 2.3-fold increases in bone volume compared to the control blank sample. Overall, the results suggest that the Fe₃O₄/PLLA nanofibers fabricated in this study may serve as a useful biomaterial for future bone tissue engineering applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404065 | PMC |
| http://dx.doi.org/10.3390/polym10070804 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Electrospun robust, biodegradable, bioactive, and nanostructured sutures to accelerate the chronic wound healing.
Biofabrication
January 2025
College of Textiles & Clothing, Qingdao University, 308 Ningxia Road, Qingdao, Qingdao, Shandong, 266071, CHINA.
The design and development of advanced surgical sutures with appropriate structure and abundant bio-functions are urgently required for the chronic wound closure and treatment. In this study, an integrated technique routine combining modified electrospinning with hot stretching process was proposed and implemented to fabricate poly(L-lactic acid) (PLLA) nanofiber sutures, and the Salvia miltiorrhiza Bunge-Radix Puerariae herbal compound (SRHC) was encapsulated into PLLA nanofibers during the electrospinning process to enrich the biofunction of as-generated sutures. All the PLLA sutures loading without or with SRHC were found to exhibit bead-free and highly-aligned nanofiber structure.
View Article and Find Full Text PDFSelf-crystal electret poly(lactic acid) nanofibers for high-flow air purification and AI-assisted respiratory diagnosis.
J Hazard Mater
December 2024
School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China; Jiangsu Engineering Research Center of Dust Control and Occupational Protection, Xuzhou 221008, China; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Chengdu 610065, China. Electronic address:
Particulate matters (PMs), one of the major airborne pollutants, continue to seriously threaten human health and the environment. Here, a self-crystal-induced electret enhancement (SCIEE) strategy was developed to promote the in-situ electret effect and polarization properties of electrospun poly(L-lactic acid) (PLLA) nanofibers. The strategy specifically involved the elaborate pre-structuring of stereocomplex crystals (SCs) with uniform dimensions (∼300 nm), which were introduced into PLLA electrospinning solution as the electrets and physical cross-linking points of high density.
View Article and Find Full Text PDFPoly l-Lactic Acid Nanofiber Membrane Effectively Inhibits Liver Cancer Cells Growth and Prevents Postoperative Residual Cancer Recurrence.
ACS Appl Mater Interfaces
January 2025
General Surgery Department, Affiliated Hospital of Yang Zhou University, Medical College of Yang Zhou University, Yang Zhou University, Yang Zhou, Jiang Su 225009, China.
Electrospun nanocarrier systems, widely employed in the medical field, exhibit the capability to encapsulate multiple drugs and mitigate complications. Doxorubicin hydrochloride (DOX) represents a frequently utilized chemotherapeutic agent for liver cancer patients. Sodium bicarbonate (SB) serves to neutralize the acidic tumor microenvironment, while ibuprofen (IBU) attenuates inflammatory factor production.
View Article and Find Full Text PDFPoly(L-lactide)/nano-hydroxyapatite piezoelectric scaffolds for tissue engineering.
Micron
January 2025
Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, Warsaw 02-105, Poland. Electronic address:
The development of bone tissue engineering, a field with significant potential, requires a biomaterial with high bioactivity. The aim of this manuscript was to fabricate a nanofibrous poly(L-lactide) (PLLA) scaffold containing nano-hydroxyapatite (nHA) to investigate PLLA/nHA composites, particularly the effect of fiber arrangement and the addition of nHA on the piezoelectric phases and piezoelectricity of PLLA samples. In this study, we evaluated the effect of nHA particles on a PLLA-based electrospun scaffold with random and aligned fiber orientations.
View Article and Find Full Text PDFBiomimetic periosteum-bone scaffolds with codelivery of BMP-2 and PDGF-BB for skull repair.
Bone
January 2025
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215300, China. Electronic address:
Tissue engineering employs the use of bioactive materials to facilitate the filling and acceleration of bone defect healing, thereby introducing novel concepts to the field of in situ bone repair. Some studies have shown that periosteum plays an important role in bone regeneration and repair. In this study, biomimetic periosteum-bone scaffolds were prepared by depositing poly-L-lactic acid (PLLA) electrospun fibers on the surface of the gelatin/chitosan cryogel to mimic the bone and periosteum structure, respectively.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!