Electrospun Combination of Peppermint Oil and Copper Sulphate with Conducive Physico-Chemical properties for Wound Dressing Applications.

Polymers (Basel)

IJNUTM Cardiovascular Engineering center, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia.

Published: April 2019

AI Article Synopsis

  • * Microscopic examinations showed changes in fiber diameter and surface roughness, with the PU/PM/CuSO₄ composite demonstrating more favorable hydrophilic properties compared to the pristine PU.
  • * Blood compatibility tests revealed improved clotting times and lower toxicity for the composites, along with higher cell viability, indicating that the PU/PM/CuSO₄ composite is better suited for wound healing applications.

Article Abstract

The ultimate goal in tissue engineering is to fabricate a scaffold which could mimic the native tissue structure. In this work, the physicochemical and biocompatibility properties of electrospun composites based on polyurethane (PU) with added pepper mint (PM) oil and copper sulphate (CuSO₄) were investigated. Field Emission Electron microscope (FESEM) study depicted the increase in mean fiber diameter for PU/PM and decrease in fiber diameter for PU/PM/CuSO₄ compared to the pristine PU. Fourier transform infrared spectroscopy (FTIR) analysis revealed the formation of a hydrogen bond for the fabricated composites as identified by an alteration in PU peak intensity. Contact angle analysis presented the hydrophobic nature of pristine PU and PU/PM while the PU/PM/CuSO₄ showed hydrophilic behavior. Atomic force microscopy (AFM) analysis revealed the increase in the surface roughness for the PU/PM while PU/PM/CuSO₄ showed a decrease in surface roughness compared to the pristine PU. Blood compatibility studies showed improved blood clotting time and less toxic behavior for the developed composites than the pristine PU. Finally, the cell viability of the fabricated composite was higher than the pristine PU as indicated in the MTS assay. Hence, the fabricated wound dressing composite based on PU with added PM and CuSO₄ rendered a better physicochemical and biocompatible nature, making it suitable for wound healing applications.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523533PMC
http://dx.doi.org/10.3390/polym11040586DOI Listing

Publication Analysis

Top Keywords

oil copper
8
copper sulphate
8
wound dressing
8
fiber diameter
8
compared pristine
8
analysis revealed
8
pu/pm pu/pm/cuso₄
8
surface roughness
8
pristine
5
electrospun combination
4

Similar Publications

Facile Synthesis of Acyl-Hydrazone Composites Based on Hydrazide-Modified Formylated Polystyrene for Effective Removal of Heavy Metal Ions and Sulfides from Water.

ACS Appl Mater Interfaces

December 2024

Oil & Gas Field Applied Chemistry Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China.

In this study, waste polystyrene was modified and upgraded to prepare formylated polystyrene, and the modified polystyrene acetyl hydrazone (LT-HPA) was synthesized by condensation with polymethyl-propionyl-hydrazine. It is proven that the modification of the adsorption material is successful by various characterization methods. In the subsequent pollutant removal study, pH, mass, concentration, contact time, and salt ion interference were investigated.

View Article and Find Full Text PDF

Background: Priming plants with natural products is extensively studied in the agricultural field to reduce the use of synthetic and copper-based pesticides. Previous studies have shown that Oregano essential oil vapour (OEOV) is an effective priming agent against downy mildew (DM) in grapevine (Vitis vinifera L. cv.

View Article and Find Full Text PDF

Shipbreaking is an extremely profitable business; however, it simultaneously destroys the surrounding environment. The discharge of toxic chemicals and materials containing wastes is contaminating surrounding water. However, there is still no sufficient published information particularly focusing on shipbreaking yard (SBY) water quality.

View Article and Find Full Text PDF

Copper-Cobalt Nanozyme Mimicking Laccase for Sensitive Colorimetric Determination of Cannabidiol in Food and Cosmetics.

Luminescence

December 2024

Key Laboratory of Intelligent Drug Control, Ministry of Education, Yunnan Key Laboratory of Intelligent Drug Control, Faculty of Narcotics Control, Yunnan Police College, Kunming, China.

In colorimetric analysis, nanozymes are invaluable tools due to their simple production, long-lasting stability, and adaptable enzymatic activity, which enable them to induce changes in substrate color. In this study, a simple nanozyme-based colorimetric sensor was developed to detect cannabidiol (CBD) by using the laccase activity of the self-made MOF with copper and cobalt loading (Cu/Co@MOF) nanozyme, which was synthesized using a one-pot microwave method. The Cu/Co@MOF has the ability to catalyze the coupling reaction between 4-AP and various phenolic substrates, thereby converting colorless phenolic substrates into red substances.

View Article and Find Full Text PDF

Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review.

Int J Mol Sci

November 2024

Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia.

Otitis media (OM) is a frequent disease with incidence rate of 5300 cases per 100,000 people. Recent studies showed that polymicrobial biofilm formation represents a significant pathogenic mechanism in recurrent and chronic forms of OM. Biofilm enables bacteria to resist antibiotics that would typically be recommended in guidelines, contributing to the ineffectiveness of current antimicrobial strategies.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: