AI Article Synopsis
- - The study aimed to explore how the fatty acid profile of breast adipose tissue relates to Inflammatory Breast Cancer (IBC), as it's believed that breast fat might impact the disease's clinical presentation.
- - Researchers analyzed breast adipose tissue samples from 234 women with breast cancer, using gas chromatography to assess fatty acid levels, noting differences related to breast inflammation.
- - Findings revealed that lower levels of beneficial fatty acids like eicosapentaenoic acid (EPA) and Gamma Linolenic acid (GLA) were linked to IBC, while higher levels of palmitic acid were associated with it, suggesting these lipid differences could play a role in breast cancer inflammation.
Article Abstract
Objective: Since it is thought that breast adipose tissue could influence breast cancer clinical presentation, we wanted to characterize specifically the relationship between breast adipose tissue fatty acid profile and Inflammatory Breast cancer (IBC).
Methods: Two hundred thirty-four women presenting with breast cancer were managed in our centre between January 2009 and December 2011. Breast adipose tissue specimens were collected during breast surgery. We established the biochemical profile of adipose tissue fatty acids (FA) by gas chromatography and assessed whether there were differences in function of the presence of breast inflammation or not.
Results: We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Inversely, an increase in palmitic acid levels was associated with IBC.
Conclusion: These differences in lipid content may contribute to the occurrence of breast cancer inflammation.
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| http://dx.doi.org/10.1016/j.breast.2019.04.001 | DOI Listing |
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