AI Article Synopsis
- - The primary consequence of prenatal Zika virus infection is severe microcephaly, primarily affecting neural progenitor cells in the brain.
- - The study explores the role of brain immune cells, called microglia, in influencing neuron survival or death during Zika virus infection.
- - Researchers cultured neural cells from neonatal rats and discovered that the immune response to Zika varies, featuring both pro-inflammatory and type I interferon reactions, influenced by the amount of virus present.
Article Abstract
The most notable effect of prenatal Zika virus (ZIKV) infection is severe microcephaly. ZIKV has a selective tropism for neural progenitor cells; however, it is not clear what role the immune cells of the brain, microglia, may have in mitigating or exacerbating neuronal cell death following ZIKV infection. We cultured hippocampal and cortical neural cells from neonatal rat pups and infected them with ZIKV at various multiplicities of infection (MOI). We found that the neuroimmune response to ZIKV infection is composed of both pro-inflammatory and type I interferon responses and is largely dependent upon the viral dose.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350658 | PMC |
| http://dx.doi.org/10.1016/j.jneuroim.2019.04.002 | DOI Listing |
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