[METHOD FOR QUANTITATIVE DETERMINATION OF PHENAZEPAM IN MIXED SALIVA].

Objective - to develop a method for the quantitative determination of the drug phenazepam in mixed saliva. For the study, samples were obtained mixed saliva in 6 patients in inpatient treatment in a psychiatric hospital. In order to correct the development of the underlying disease, patients took the drug - phenazepam. For comparison, samples of mixed saliva of healthy volunteers (n=6) who did not take medications were studied. A technique has been developed for the quantitative determination of the drug phenazepam in mixed saliva on a Sciex 4500 triple quadrupole liquid chromatography-mass spectrometer with ionization, separation and detection of samples. Allows you to determine the concentration of phenazepam in mixed saliva with an accuracy of from 102 to 109% and can be used to control the removal and dosing of drugs.