[PECULIARITIES OF IMMUNE PROFILE IN BLOOD OF RATS IN THE DYNAMICS OF IMMOBILIZATION STRESS ON THE BACKGROUND OF HYPOTHYROIDISM].

The aim of our study was to investigate the peculiarities of changes in the indices of cellular and humoral immunity in the case of immobilization stress, which is implemented against the background of hypothyroidism. It was used 84 white Wistar male rats to study the peculiarities of the stress reaction against hypothyroidism. The study of cellular and humoral immunity was performed on a Beckman Coulter Epics-XL flow cytometer. During the immobilization stress in rats, the cellular immunity indices reliably decrease at the anxiety stage with adaptation to the effect of stress after 48 h in the resistance stage with subsequent exhaustion of the adaptation reserves at the depletion stage. Against the background of a decrease in the T-lymphocyte level at the anxiety stage, the B-lymphocyte population significantly increased (by 26.5%). In animals with deficiency of iodine-containing thyroid hormones, we noted a significant decrease in cellular and humoral immunity at all stages of immobilization stress, which was accompanied by a significant decrease of immunoregulatory index (p<0.05).