AI Article Synopsis
- - The text discusses the role of interleukin (IL)-17, a key proinflammatory cytokine, in the development of ankylosing spondylitis (AS) and axial spondyloarthritis (axSpA), highlighting its significance in the disease's immunopathogenesis.
- - It reviews the effectiveness and safety of IL-17A inhibitors like secukinumab and ixekizumab and provides insight into ongoing research on additional IL-17 inhibitors such as bimekizumab and brodalumab.
- - The expert opinion emphasizes that IL-17 inhibitors enhance treatment options for AS, demonstrating effectiveness even in patients who have not responded to tumor necrosis factor inhibitors while maintaining a reasonable safety profile.
Article Abstract
Introduction: Interleukin (IL)-17 is a proinflammatory cytokine considered to play a significant role in the immunopathogenesis of ankylosing spondylitis (AS)/axial spondyloarthritis (axSpA) as well as of other spondyloarthritides. There is a number of substances targeting IL-17, which are at different stages of development in the axSpA indication.
Areas Covered: This review summarizes the current evidence on the role of IL-17 in the pathophysiology of axSpA and provided a comprehensive review of clinical and radiographic outcomes as well as of safety data from studies with IL-17A inhibitors secukinumab and ixekizumab. Ongoing studies on other IL-17 inhibitors (bimekizumab, brodalumab and BCD-085) that are being developed are also summarized.
Expert Opinion: The development of the IL-17 inhibitors has expanded AS treatment with effective options and confirmed the pathophysiological role of IL-17 in axSpA. IL-17 inhibition showed sufficient efficacy against signs and symptoms of the disease even after the failure of tumor necrosis factor inhibitors, being at the same time reasonably safe.
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| http://dx.doi.org/10.1080/14712598.2019.1605352 | DOI Listing |
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