Free amino group-directed C(sp)-H functionalization of aliphatic amines is a fundamental challenge in synthetic organic chemistry. Also, the NH-directed C(sp)-H functionalization of α-amino acids and their derivatives remains barely explored. With palladium as the catalyst and AgO as the additive, we developed the first NH-directed γ-C(sp)-H arylation of α-amino esters with diaryliodonium triflates for the construction of synthetically useful γ-aryl-α-amino esters, and the result of the KIE study suggested that the catalytic reaction involved an irreversible C-H cleavage as the rate-determining step.
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