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Clinico-pathologic correlation in ocular sarcoidosis.
Am J Ophthalmol Case Rep
December 2024
Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Purpose: This case describes the unique course and management of a patient with progressive, refractory multi-system sarcoidosis that initially presented with ocular and dermatologic findings.
Observations: A 47-year-old male presented with acute anterior uveitis and was found to have simultaneous inflammation of his skin at a tattoo site. Diagnosis of ocular sarcoidosis was confirmed through skin biopsy.
Characterisation and management of expected and unexpected urgent findings from positron emission tomography with F-fluorodeoxyglucose integrated with computed tomography in cardiovascular disease.
J Nucl Cardiol
May 2024
Royal Brompton Hospital, Part of Guy's and St Thomas' NHS Foundation Trust, UK. Electronic address:
Background: Cardiac F-fluorodeoxyglucose (FDG)-PET-CT plays an important role in the assessment of cardiovascular diseases. Effective management of urgent scan findings facilitates optimal patient care.
Methods: We characterised the management of urgent, expected and unexpected findings in patients referred for cardiac [F]fluorodeoxyglucose integrated with computed tomography (FDG-PET-CT) at the Royal Brompton Hospital (United Kingdom).
The Relationship Between Serum Angiotensin Converting Enzyme Level and the Decision to Escalate Treatment of Sarcoidosis.
Lung
August 2023
Department of Medicine, Division of Pulmonary and Critical Care Medicine MC-91, Albany Medical College, 16 New Scotland Avenue, Albany, NY, 12208, USA.
Purpose: We performed a retrospective analysis of a sarcoidosis cohort who had sACE obtained at their initial clinic visit, but the treating physician was blinded to the results. We examined the relationship between sACE and the treating physician's decision to escalate sarcoidosis treatment.
Methods: Treatment was considered escalated if the prednisone dose was increased or if the prednisone dose was not changed but an additional anti-sarcoidosis drug was added or the dose was increased.
Efzofitimod: a novel anti-inflammatory agent for sarcoidosis.
Sarcoidosis Vasc Diffuse Lung Dis
March 2023
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Article Synopsis
- - Efzofitimod is a novel biologic that targets immune responses by modulating neuropilin-2 (NRP2), which is highly expressed in sarcoidosis granulomas.
- - Preclinical tests showed that efzofitimod effectively reduced inflammation caused by P. acnes in an animal model of sarcoidosis.
- - A dose escalation trial in humans indicated that efzofitimod improved quality of life, reduced reliance on glucocorticoids, and stabilized or improved lung function in patients with chronic pulmonary sarcoidosis, leading to a larger Phase 3 trial.
The course of non-infectious uveitis in pregnancy: a retrospective study of 79 pregnancies.
Graefes Arch Clin Exp Ophthalmol
May 2023
Service de Médecine Interne, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
Purpose: The study aims to describe the course and management of non-infectious uveitis during pregnancy and postpartum period in European populations.
Methods: A retrospective observational study in two tertiary centers in France was performed. Pregnant patients during the follow-up of a non-infectious uveitis as well as those with new-onset uveitis were included.
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