The present report documents 6 patients who developed distinctive hyperpigmented skin lesions after bleomycin sclerotherapy for vascular malformations of the face, neck, and extremities. The patients ranged in age from 2 to 65 years and included both black and white and male and female patients. The bleomycin treatment dose varied from 15 to 45 U, with 5 of the 6 patients receiving foamed bleomycin. The hyperpigmented lesions were near the patient's vascular anomaly and attributable to postprocedural cutaneous pressure (eg, electrocardiographic [ECG] leads or tape). Hyperpigmentation faded slowly over time but was visible up to 3 years after the procedure.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvir.2018.10.007DOI Listing

Publication Analysis

Top Keywords

foamed bleomycin
8
bleomycin sclerotherapy
8
sclerotherapy vascular
8
vascular malformations
8
hyperpigmentation foamed
4
bleomycin
4
malformations report
4
report documents
4
patients
4
documents patients
4

Similar Publications

Bleomycin Polidocanol Foam (BPF) Stability - In Vitro Evidence for the Effectiveness of a Novel Sclerosant for Venous Malformations.

Eur J Vasc Endovasc Surg

June 2020

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, Shanghai, PR China. Electronic address:

Objective: This study investigated the in vitro stability of a novel sclerosant, bleomycin polidocanol foam (BPF), for venous malformation (VM) sclerotherapy.

Methods: The study was designed with control groups treated with polidocanol (0.5%, 1%, and 3%) only.

View Article and Find Full Text PDF

The present report documents 6 patients who developed distinctive hyperpigmented skin lesions after bleomycin sclerotherapy for vascular malformations of the face, neck, and extremities. The patients ranged in age from 2 to 65 years and included both black and white and male and female patients. The bleomycin treatment dose varied from 15 to 45 U, with 5 of the 6 patients receiving foamed bleomycin.

View Article and Find Full Text PDF

Objectives/hypothesis: To assess clinical outcomes of patients with airway venous malformations treated with percutaneous sclerotherapy (VMPS). We highlight the role of foamed bleomycin as a less inflammatory sclerosant and the importance of collaboration between interventional radiology and otolaryngology-head and neck surgery (OHNS).

Study Design: Retrospective, consecutive, single-center series.

View Article and Find Full Text PDF

Bleomycin Foam Treatment of Venous Malformations: A Promising Agent for Effective Treatment with Minimal Swelling.

J Vasc Interv Radiol

October 2015

Divisions of Cardiovascular and Interventional Radiology, Russell H. Morgan Department of Radiology and Radiologic Science, The Johns Hopkins University School of Medicine, 601 N. Caroline St., Room 3125, Baltimore, MD 21287.

Purpose: To report clinical and radiographic outcomes of patients with venous malformations (VMs) treated with bleomycin foam.

Materials And Methods: Twenty patients (age, 2-68 y) presented with symptoms of swelling (n = 19; 95%), pain (n = 14; 70%), and bleeding (n = 4; 20%). Lesions were located in the head and neck in 17 patients (85%), extremities in two (10%), and mediastinum in one (5%).

View Article and Find Full Text PDF

Silicone foam containing BLM and implanted in the cavity resulting from the resection of a tumor seemed to act against any tumor cells remaining in the resection site in microscopic amounts by slowly releasing this carcinostatic agent. The silicone foam is molded in precise accordance with the shape of the wound surface as it foams and hardens, leaving no space between the material and the wound surface. The carcinostatic agent released can, therefore, act on the entire surface of the wound, and the implantation also has a hemostatic effect.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!