AI Article Synopsis
- Exposure to the sun leads to photoaging, which presents differently in individuals, with atrophic (thin, less severe) and hypertrophic (thick, more severe) types having distinct characteristics.
- A study of 53 participants classified their photoaging type and examined clinical features alongside facial biopsies for gene expression and histologic analysis.
- Results showed that atrophic photoaging had less severe signs and fewer complications compared to hypertrophic photoaging, while gene expression patterns were similar between the two forms.
Article Abstract
Background: Exposure to the sun causes premature skin aging, known as photoaging. Clinical features of photoaging vary widely among individuals. In one form, skin appears thin with telangiectasia, and in another form, skin appears thickened with coarse wrinkles. Etiologic, clinical, and therapeutic distinctions among different forms of photoaging remain largely unknown.
Objective: To characterize the clinical, histologic, and molecular features of hypertrophic and atrophic photoaging.
Methods: In total, 53 individuals were clinically classified as having primarily atrophic or hypertrophic photoaging or neither (controls). Participants' demographic and sun exposure-related lifestyle data were captured by questionnaire. Fifteen clinical features of participants were qualitatively or quantitively scored. Facial biopsies were analyzed for gene expression and histologic characteristics.
Results: Actinic and seborrheic keratosis, telangiectasia, and prior incidence of skin cancers were statistically significantly greater and photoaging scale severity, coarse wrinkles, thickness, and sallowness were significantly reduced in atrophic versus hypertrophic groups. Histology also revealed significantly less elastotic material in atrophic photoaging. Gene expression of matrix metalloproteinases and collagens did not differ between the 2 forms of photoaging.
Limitations: The study was not designed to identify other possible subtypes of photoaging.
Conclusion: Systematic, categorical, and quantitative clinical and histologic assessments distinguish atrophic and hypertrophic photoaging.
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| http://dx.doi.org/10.1016/j.jaad.2019.03.081 | DOI Listing |
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