AI Article Synopsis
- - This report highlights the first case of a persistent oropharyngeal infection with a type 2 poliovirus variant (iVDPV2) in a patient with primary immune deficiency, following the eradication of wild type 2 poliovirus.
- - The iVDPV2 was found to persist not only in the throat but also in the gut, indicating its ability to survive in multiple locations within the body.
- - The evolution of iVDPV2 in both the throat and gut occurred independently, raising concerns about the risk of oral and fecal transmission as the world aims for complete eradication of poliovirus type 2.
Article Abstract
This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world.
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| http://dx.doi.org/10.1016/j.ijid.2019.03.037 | DOI Listing |
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