Using a Systems Biology Approach To Study Host-Pathogen Interactions.

Microbiol Spectr

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

Published: March 2019

The rapid development of genomics and other "-omics" approaches has significantly impacted how we have investigated host-pathogen interactions since the turn of the millennium. Technologies such as next-generation sequencing, stem cell biology, and high-throughput proteomics have transformed the scale and sensitivity with which we interrogate biological samples. These approaches are impacting experimental design in the laboratory and transforming clinical management in health care systems. Here, we review this area from the perspective of research on bacterial pathogens.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590422PMC
http://dx.doi.org/10.1128/microbiolspec.BAI-0021-2019DOI Listing

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