Though the Corsi block-tapping task (CBT) is widely used for assessing visuospatial memory, information about what exactly it measures is still debated. We investigated such issue by observing how motor, visual, and spatial secondary tasks affect the performance on three versions of the CBT. Results showed a double dissociation pattern, wherein two motor secondary tasks had larger effects when the CBT was administered by the examiner tapping on the blocks. A spatial secondary task had larger effects when the CBT was administered by automatically illuminating the blocks. Finally, a visual secondary task had larger effects on a two-dimensional, computerized version of the CBT. These findings suggest that memory for movements plays a relevant role in the CBT, and are especially relevant due to their implications for assessment of brain-damaged patients, besides providing further evidence of a fractionation of visuospatial memory into multiple subcomponents.
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http://dx.doi.org/10.1007/s10339-019-00917-y | DOI Listing |
J Am Chem Soc
December 2024
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
The catalytic behavior of a material is influenced by ensembles─the geometric configuration of atoms on the surface. In conventional material systems, ensemble effects and the electronic structure are coupled because these strategies focus on varying the material composition, making it difficult to understand the role of ensembles in isolation. This study introduces a methodology that separates geometric effects from the electronic structure.
View Article and Find Full Text PDFCereb Cortex
December 2024
Rockefeller Neuroscience Institute 33 Medical Center Dr. Morgantown, WV 26505, United States.
Early-onset Alzheimer's disease (EOAD) is less investigated than the more common late-onset Alzheimer's disease (LOAD) despite its more aggressive course. A cortical signature of EOAD was recently proposed and may facilitate EOAD investigation. Here, we aimed to validate this proposed MRI biomarker of EOAD neurodegeneration in an Appalachian clinical cohort.
View Article and Find Full Text PDFFASEB J
December 2024
Systems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama, Japan.
Flavan-3-ols (FL) are poorly bioavailable astringent polyphenols that induce hyperactivation of the sympathetic nervous system. The aim of this study was to investigate the effects of repeated oral administration of FL on mice hindlimb skeletal muscle using immunohistochemical techniques. C57BL/6J male mice were orally administered 50 mg/kg of FL for a period of 2 weeks, and bromideoxyuridine (BrdU) was administered intraperitoneally 3 days prior to the dissection.
View Article and Find Full Text PDFJMIR Res Protoc
December 2024
Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States.
Background: Pediatric patients with cancer have limited options to self-manage their health while they are undergoing treatments in the hospital and after they are discharged to their homes. Extended reality (ER) using head-mounted displays has emerged as an immersive method of improving pain and mental health and promoting health-enhancing physical activity among a variety of clinical groups, but there is currently no established protocol for improving both physical and mental health in pediatric cancer rehabilitation.
Objective: This phase I, pilot, feasibility randomized controlled trial aims to investigate the potential effects of a 14-week ER program on physical activity participation and indicators of health among pediatric patients with cancer who undergo bone marrow transplantation.
Muscle Nerve
December 2024
Aix-Marseille Univ, CNRS, CRMBM, Marseille, France.
Introduction And Aims: Mitochondrial myopathies are rare genetic disorders for which no effective treatment exists. We previously showed that the pharmacological cyclophilin inhibitor cyclosporine A (CsA) extends the lifespan of fast-twitch skeletal muscle-specific mitochondrial transcription factor A knockout (Tfam KO) mice, lacking the ability to transcribe mitochondrial DNA and displaying lethal mitochondrial myopathy. Our present aim was to assess whether the positive effect of CsA was associated with improved in vivo mitochondrial energy production.
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