A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models.

Parkinson's disease (PD) severely affects life quality of patients and has brought huge economic burden to health system worldwide. Previous studies have shown that the abnormal expression of hydrogen peroxide (HO) in the brain is closely related to the development of neurodegenerative diseases such as PD. Herein, we designed a novel deep-red HO fluorogenic probe PB1 to detect the level of HOin vivo. PB1 showed a highly selectivity response to HO over other reactants such as reactive oxygen/nitrogen species, biothiols and various ions in aqueous solution at physiological pH. We have demonstrated that PB1 possesses an excellent response to HO in the cells and in the brain tissue of drosophila from confocal fluorescence imaging. These results suggested that PB1 holds great potential in the study of the relationship between HO overexpression and PD.