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Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health.
Cardiovasc Diabetol
December 2024
Institute of Physiology, iCBR, Faculty of Medicine, University of Coimbra, Subunit 1, polo 3, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Perivascular adipose tissue (PVAT) is a dynamic tissue that affects vascular function and cardiovascular health. The connection between PVAT, the immune system, obesity, and vascular disease is complex and plays a pivotal role in the pathogenesis of vascular diseases such as atherosclerosis, hypertension, and vascular inflammation. In cardiometabolic diseases, PVAT becomes a significant source of proflammatory adipokines, leading to increased infiltration of immune cells, in cardiometabolic diseases, PVAT becomes a significant source of proinflammatory adipokines, leading to increased infiltration of immune cells, promoting vascular smooth muscle cell proliferation and migrationpromoting vascular smooth muscle cell proliferation and migration.
View Article and Find Full Text PDFHIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo-YAP pathway activation.
Mol Med
December 2024
Department of Otorhinolaryngology/Head and Neck, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No.3 East Qingchun Road, Hangzhou, 310020, Zhejiang, China.
Background: Sleep apnea syndrome (SAS) is associated with hypertension and vascular remodeling. Hypoxia-inducible factor-1α (HIF-1α) and the Hippo-YAP pathway are implicated in these processes, but their specific roles remain unclear. This study investigated the HIF-1α/Hippo-YAP pathway in SAS-related hypertension.
View Article and Find Full Text PDFEvaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age.
Cardiovasc Diabetol
December 2024
Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, s7-119, New York, NY, USA.
Background: Long-term consumption of Western Diet (WD) is a well-established risk factor for the development of cardiovascular disease (CVD); however, there is a paucity of studies on the long-term effects of WD on the pathophysiology of CVD and sex-specific responses.
Methods: Our study aimed to investigate the sex-specific pathophysiological changes in left ventricular (LV) function using transthoracic echocardiography (ECHO) and LV tissue transcriptomics in WD-fed C57BL/6 J mice for 125 days, starting at the age of 300 through 425 days.
Results: In female mice, consumption of the WD diet showed long-term effects on LV structure and possible development of HFpEF-like phenotype with compensatory cardiac structural changes later in life.
Multi-Energy Evaluation of Image Quality in Spectral CT Pulmonary Angiography Using Different Strength Deep Learning Spectral Reconstructions.
Acad Radiol
December 2024
Radiomics and Augmented Intelligence Laboratory (RAIL), Department of Radiology and the Norman Fixel Institute for Neurological Diseases, University of Florida College of Medicine, Gainesville, FL (M.H-S., H.S.S., A.G.R., S.E.M., J.C.P., E.Y.A., B.H., R.F.); Department of Radiology, University of Florida College of Medicine, Gainesville, FL (M.H-S., H.S.S., A.G.R., J.C.P., E.Y.A., B.H., R.F.); Division of Medical Physics, University of Florida College of Medicine, Gainesville, FL (R.F.); Department of Neurology, Division of Movement Disorders, University of Florida College of Medicine, Gainesville, FL (R.F.); Department of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Quebec, Canada (R.F.); Department of Radiology, AdventHealth Medical Group, Maitland, FL (R.F.). Electronic address:
Rationale And Objectives: To evaluate and compare image quality of different energy levels of virtual monochromatic images (VMIs) using standard versus strong deep learning spectral reconstruction (DLSR) on dual-energy CT pulmonary angiogram (DECT-PA).
Materials And Methods: A retrospective study was performed on 70 patients who underwent DECT-PA (15 PE present; 55 PE absent) scans. VMIs were reconstructed at different energy levels ranging from 35 to 200 keV using standard and strong levels with deep learning spectral reconstruction.
Polyneuropathy in Parkinson's Disease is Highly Prevalent and Not Related to Treatment.
Clin Ther
December 2024
Neurology Department, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom; Department of Psychology, Manchester Metropolitan University, Manchester, United Kingdom.
Purpose: An increased prevalence of peripheral polyneuropathy (PN) in Parkinson's disease (PD) associated with greater functional impairment has previously been reported. A possible cause has been suggested as levodopa therapy. The aim of this real-world study was to assess the prevalence and the characteristics of PN in PD and to investigate the putative association between PN and oral levodopa.
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