Development of liposomes using formulation by design: Basics to recent advances.

In couple of decennia, optimization tactics for drug delivery systems have been explored widely employing Design of Experiments (DoE) for desired outcomes to overcome drawbacks of "One Factor at a Time (OFAT)"conventional technique.. To pace with advances in computational approaches engaged in research domain, QbD-based tactic i.e. Formulation by Design (FbD) is under extensive investigation by budding scientists for better know-how of the product and process development for an unequivocal universal acceptation. Like other vesicular drug carriers, liposomes also demand robustness and reproducibility to scale up at industrial outset. Based on said outlook, this review focuses on the fundamentals and methodologies like Central Composite, Simplex Mixture, Box-Behnken, Factorial, Taguchi, Simplex Centroid, d-optimal, Placket Burman, and Orthogonal array with special reference to applications of FbD in the development of liposomes.