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Performance of sentinel lymph node biopsy after neoadjuvant chemotherapy in clinically node positive breast cancer patients: systematic review and meta-analysis.
Int J Surg
January 2025
Department of Surgery, American University of Beirut, Beirut, Lebanon.
Background: The reliability of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in patients with initially node-positive breast cancer is still controversial. This meta-analysis is conducted to investigate the feasibility and accuracy of SLNB after NACT in patients with initially positive axillary nodes.
Methods: We conducted a literature search using Medline, PubMed, Embase, Central, and SCOPUS up until April 2021 for studies on the performance of SLNB following NACT.
From Mapping to Elimination: A Comprehensive Overview of Rwanda's Schistosomiasis Program.
Int J Infect Dis
January 2025
END Fund, New York, USA. Electronic address:
Objectives: Schistosomiasis (SCH) remains a public health challenge in Rwanda despite ongoing interventions. This paper provides an overview of Rwanda's SCH journey, highlighting progress made through mass drug administration (MDA), diagnostic advancements, and strategic partnerships with key stakeholders.
Methods: Since 2014, the point-of-care circulating cathodic antigen (POC-CCA) test has been introduced alongside Kato-Katz (KK), improving mapping accuracy and detecting low-intensity infections.
Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using .
bioRxiv
January 2025
Nicholas School of the Environment, Duke University, Durham, North Carolina, USA.
Few of the many chemicals that regulatory agencies are charged with assessing for risk have been carefully tested for developmental neurotoxicity (DNT). To speed up testing efforts, as well as to reduce the use of vertebrate animals, great effort is being devoted to alternate laboratory models for testing DNT. A major mechanism of DNT is altered neuronal architecture resulting from chemical exposure during neurodevelopment.
View Article and Find Full Text PDFConfirmatory mapping for lymphatic filariasis in districts previously considered non-endemic in Ghana.
Int J Infect Dis
January 2025
FHI 360, Abidjan, Cote d'Ivoire. Electronic address:
Objectives: Lymphatic filariasis (LF) elimination efforts in Ghana have been ongoing since 2001, achieving substantial progress through mass drug administration (MDA). However, despite significant advances, LF transmission persists in certain areas. Some districts previously classified as non-endemic have reported lymphedema and hydrocele cases, raising concerns about LF endemicity.
View Article and Find Full Text PDFTheory-informed refinement and tailored implementation of a quality improvement program in maternity care to reduce unwarranted clinical variation across a health service network.
BMC Health Serv Res
January 2025
Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Background: Unwarranted clinical variation presents a major challenge in contemporary healthcare, indicating potential inequalities and inefficiencies, and unrealised potential for better outcomes. Despite an increasing focus on unwarranted clinical variation, and consideration of efforts to address this challenge, evidence-based strategies which achieve this are limited. Audit and feedback of healthcare processes (process auditing) and clinician engagement are important tools which may help to reduce unwarranted clinical variation, however their application in maternity care is yet to be thoroughly explored.
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