AI Article Synopsis
- Millions of oocytes and embryos are increasingly stored worldwide due to successful cryopreservation, leading to concerns around viability and contamination.
- Studies indicate that frozen embryo transfer (FET) has better outcomes regarding small for gestational age and preterm births, but it may also increase the risk of larger-than-average births.
- There is a pressing need for research to address the risks associated with cryostorage, which could help reproductive clinics implement better management strategies as the field moves towards automation.
Article Abstract
Millions of human oocytes and embryos are stored in thousands of locations across the globe. This inventory continues to grow as cryopreservation becomes more successful and more widely applied. The results of studies assessing pregnancy and neonatal outcomes following frozen embryo transfer (FET) have been encouraging, showing lower incidences of small for gestational age neonates and preterm birth compared with fresh transfers. However, many of these studies have also shown that the odds of large for gestational age births and macrosomia are higher after FET. The origin of these conditions remains unclear. Cryostorage presents many potential risks to the cryopreserved cells/tissues, including loss of viability and contamination, but risks are faced also by care providers-for example, injury and financial liability-and by patients-for example, accidental loss of their reproductive tissues, the burden of embryos they no longer wish to use and failing to meet their contractual obligations. Studies are urgently needed to explore and understand all dimensions of cryostorage to help ART clinics develop effective strategies to manage associated risks. The future of cryostorage, as for many other areas of ART and medicine, is automation.
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| http://dx.doi.org/10.1055/s-0038-1676849 | DOI Listing |
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