In this work, a conceptual process design of wastewater-based algal biofuels production through hydrothermal liquefaction and hydroprocessing is proposed. Then a steady-state process simulation is performed to calculate the mass and energy analysis of the whole process for the production of hydrocarbons such as diesel, jet, gasoline, and H. A discounted cash flow analysis is used to calculate a minimum selling price (MSP) of the hydrocarbon fuels. The MSP of the hydrocarbon fuels is found at US$4.3/GGE. This value is comparable with the previously reported value in the literature. In addition, the sensitivity study is carried out to study the influence of both processes and economic parameters on the minimum selling price (MSP) of the hydrocarbon fuels.
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http://dx.doi.org/10.1016/j.biortech.2019.03.087 | DOI Listing |
Malar J
September 2024
Department of Biology, Arba Minch University, Arba Minch, Ethiopia.
Background: Artemether-lumefantrine (AL) has been the primary anti-malarial drug used to treat uncomplicated Plasmodium falciparum malaria in Ethiopia since 2004. However, there have been recent reports of AL resistance mutations in different African countries, including Ethiopia. This is concerning and requires periodic monitoring of anti-malarial drug resistance.
View Article and Find Full Text PDFPhytomedicine
September 2024
Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 115024, Taiwan. Electronic address:
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type that urgently requires effective therapeutic strategies. Andrographolide, a labdane diterpenoid compound abundant in Andrographis paniculata, has anticancer effects against various cancer types, but its anticancer activity and mechanism against PDAC remain largely uncharacterized.
Purpose: This study explores novel drug target(s) and underlying molecular mechanism of andrographolide against PDAC.
J Biol Chem
August 2024
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, Delhi, India. Electronic address:
Emerging Artemisinin (ART) resistance in Plasmodium falciparum (Pf) poses challenges for the discovery of novel drugs to tackle ART-resistant parasites. Concentrated efforts toward the ART resistance mechanism indicated a strong molecular link of ART resistance with upregulated expression of unfolded protein response pathways involving Prefoldins (PFDs). However, a complete characterization of PFDs as molecular players taking part in ART resistance mechanism, and discovery of small molecule inhibitors to block this process have not been identified to date.
View Article and Find Full Text PDFInt Immunopharmacol
September 2024
Department of Otorhinolaryngology-Head& Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China. Electronic address:
Background: Our previous research demonstrated that resveratrol counters DDP-induced ototoxicity by upregulating miR-455-5p, which targets PTEN. This study aimed to elucidate the underlying mechanisms involving GAS5 and DNA methyltransferase 1 (DNMT1) in resveratrol's protective action.
Methods: A luciferase reporter assay and RNA immunoprecipitation (RIP) assay were employed to study the binding between GAS5 and miR-455-5p, as well as between miR-455-5p and PTEN.
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