Zebrafish larvae have several biological features that make them useful for cellular investigations of the mechanisms underlying learning and memory. Of particular interest in this regard is a rapid escape, or startle, reflex possessed by zebrafish larvae; this reflex, the C-start, is mediated by a relatively simple neuronal circuit and exhibits habituation, a non-associative form of learning. Here we demonstrate a rapid form of habituation of the C-start to touch that resembles the previously reported rapid habituation induced by auditory or vibrational stimuli. We also show that touch-induced habituation exhibits input specificity. This work sets the stage for in vivo optical investigations of the cellular sites of plasticity that mediate habituation of the C-start in the larval zebrafish.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449028 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214374 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Rapid detection of drug abuse via tear analysis using surface enhanced Raman spectroscopy and machine learning.
Sci Rep
January 2025
Department of Ophthalmology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, 134 Dongjie Rd, Fuzhou, 350001, Fujian, China.
With the growing global challenge of drug abuse, there is an urgent need for rapid, accurate, and cost-effective drug detection methods. This study introduces an innovative approach to drug abuse screening by quickly detecting ephedrine (EPH) in tears using drop coating deposition-surface enhanced Raman spectroscopy (DCD-SERS) combined with machine learning (ML). Using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), the average concentration of EPH in tear fluid of Sprague-Dawley (SD) rats, measured over 3 h post-injection, was 1235 ng/mL.
View Article and Find Full Text PDFHabituation of the biological response to repeated psychosocial stress: a systematic review and meta-analysis.
Neurosci Biobehav Rev
January 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany; Center for Mind, Brain and Behaviour, Philipps University Marburg, Hans-Meerwein-Str. 6, 35032 Marburg, Germany. Electronic address:
Recurrent psychosocial stress poses a significant health challenge, prompting research into mechanisms of successful adaptation. Physiological habituation, defined as decreased reactivity to repeated stressors, is pivotal in protecting the organism from allostatic load. Here, we systematically review and meta-analyze data from studies investigating the capacity of central stress systems to habituate when repeatedly exposed to a standardized psychosocial stressor, the Trier Social Stress Test (k=47).
View Article and Find Full Text PDF[Discontinuation of psychotropic medication: a critical review of the evidence].
Tijdschr Psychiatr
January 2025
Background: Pharmacotherapy is an effective treatment strategy for psychiatric disorders. Nevertheless, many patients discontinue their medication at some point. Evidence-based practices for patients, clinicians, and policymakers to discontinue psychotropic medication properly are therefore important.
View Article and Find Full Text PDFProbing Sensorimotor Memory through the Human Speech-Audiomotor System.
J Neurophysiol
December 2024
Yale Child Study Center, Yale School of Medicine, Yale University, New Haven, CT, USA.
Our knowledge of human sensorimotor learning and memory is predominantly based on the visuo-spatial workspace and limb movements. Humans also have a remarkable ability to produce and perceive speech sounds. We asked if the human speech-auditory system could serve as a model to characterize retention of sensorimotor memory in a workspace which is functionally independent of the visuo-spatial one.
View Article and Find Full Text PDFRapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.
Nat Commun
December 2024
Pharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Ovarian-derived estrogen can signal non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. Early alcohol drinking confers greater risk for alcohol use disorder in women than men, and binge alcohol drinking is correlated with high estrogen levels, but a causal role for estrogen in driving alcohol drinking has not been established. We found that female mice displayed greater binge alcohol drinking and reduced avoidance when estrogen was high during the estrous cycle than when it was low.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!