Delicate molecular and biological motors are tiny machines capable of achieving numerous vital tasks in biological processes. To gain a deeper understanding of their mechanism of motion, researchers from multiple backgrounds have designed and fabricated artificial micro- and nanomotors. These nano-/microscale motors can self-propel in solution by exploiting different sources of energy; thus showing tremendous potential in widespread applications. As one of the most common motor systems, Janus motors possess unique asymmetric structures and integrate different functional materials onto two sides. This review mainly focuses on the fabrication of different types of micro- and nanomotors based on Janus structures. Furthermore, some challenges still exist in the implementation of Janus motors in the biomedical field. With such common goals in mind, it is expected that the elaborate and multifunctional design of Janus motors will overcome their challenges in the near future.
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http://dx.doi.org/10.1002/chem.201900840 | DOI Listing |
Bioconjug Chem
December 2024
School of Medicine and Health, Harbin Institute of Technology, Harbin 150080, China.
Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By transforming various energy sources into mechanical motion, MNMs are able to autonomously navigate through complex physiological environments, facilitating targeted delivery of therapeutic agents to previously inaccessible regions. However, to achieve efficient in vivo drug delivery, biomedical MNMs must demonstrate their ability to overcome crucial physiological barriers encompassing mucosal surfaces, blood flow dynamics, vascular endothelium, and cellular membrane.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, PR China. Electronic address:
Contemporary industrial production and human activity release numerous toxins into our environment. Metal-organic frameworks (MOFs) are potential candidates for addressing these toxins due to their ultrahigh surface area, tailored pore size, and responsiveness to stimuli. With the rise of micro/nanomotor, imparting active motion to MOFs becomes crucial for efficiently performing tasks in challenging locations.
View Article and Find Full Text PDFSmall
December 2024
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology (BIST), Av. Països Catalans, 16, Tarragona, E-43007, Spain.
Micro/nanomotors (MNMs) are highly versatile small-scale devices capable of converting external energy inputs into active motion. Among the various energy sources, light stands out due to its abundance and ability to provide spatiotemporal control. However, the effectiveness of light-driven motion in complex environments, such as biological tissues or turbid water, is often limited by light scattering and reduced penetration.
View Article and Find Full Text PDFACS Omega
December 2024
Metamaterials Laboratory, Electrical and Computer Engineering Department, Northeastern University, Boston, Massachusetts 02115, United States.
Janus micro- and nanoparticles, featuring unique dual-interface designs, are at the forefront of rapidly advancing fields such as optics, medicine, and chemistry. Accessible control over the position and orientation of Janus particles within a cluster is crucial for unlocking versatile applications, including targeted drug delivery, self-assembly, micro- and nanomotors, and asymmetric imaging. Nevertheless, precise mechanical manipulation of Janus particles remains a significant practical challenge across these fields.
View Article and Find Full Text PDFPhys Chem Chem Phys
December 2024
College of Chemistry, Changchun Normal University, Changchun 130032, China.
Janus particles, consisting of two or more chemically distinct composites within a single structural system, have attracted significant attention for their solid surfactant functionality, as well as their potential applications in micro/nanomotors and functional materials. Here, we present a simple and robust method to prepare plasmonic Janus particles consisting of a polystyrene-tethered gold nanorod (AuNRs@PS) head and a poly(4-vinylpyridine) (P4VP) head through emulsion confined assembly. The balance of the Janus particles can be finely tuned by adjusting the volume ratio of the AuNRs@PS solution and P4VP solution.
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