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| http://dx.doi.org/10.1111/joa.12988 | DOI Listing |
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Cournand's and Richards' Post-Nobel Challenge: "Do Anything on the Structure of the Lung That Is of Interest for Physiology".
Ann Am Thorac Soc
February 2018
Institute of Anatomy, University of Bern, Bern, Switzerland.
In their Nobel Lectures of 1956, the two cardiopulmonary physiologists André Cournand and Dickinson Richards described the future projects that they considered important for rounding up their impressive scientific achievements. One of them called for work that brought together structure and function of the lung in a systematic way. They challenged a young anatomist to undertake this in their cardiopulmonary laboratory at Bellevue Hospital.
View Article and Find Full Text PDFMultiscale Lung Imaging Provides New Insights into Disease Progression in the Chronic Obstructive Pulmonary Disease Lung.
Am J Respir Crit Care Med
March 2017
4 Institute of Anatomy University of Bern Bern, Switzerland.
Lung morphometry: the link between structure and function.
Cell Tissue Res
March 2017
Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH-3000, Bern 9, Switzerland.
The study of the structural basis of gas exchange function in the lung depends on the availability of quantitative information that concerns the structures establishing contact between the air in the alveoli and the blood in the alveolar capillaries, which can be entered into physiological equations for predicting oxygen uptake. This information is provided by morphometric studies involving stereological methods and allows estimates of the pulmonary diffusing capacity of the human lung that agree, in experimental studies, with the maximal oxygen consumption. The basis for this "machine lung" structure lies in the complex design of the cells building an extensive air-blood barrier with minimal cell mass.
View Article and Find Full Text PDFMorphometric differences between central vs. surface acini in A/J mice using high-resolution micro-computed tomography.
J Appl Physiol (1985)
July 2016
Department of Radiology, University of Iowa, Iowa City, Iowa; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa; Department of Medicine, University of Iowa, Iowa City, Iowa;
Through interior tomography, high-resolution microcomputed tomography (μCT) systems provide the ability to nondestructively assess the pulmonary acinus at micron and submicron resolutions. With the application of systematic uniform random sampling (SURS) principles applied to in situ fixed, intact, ex vivo lungs, we have sought to characterize morphometric differences in central vs. surface acini to better understand how well surface acini reflect global acinar geometry.
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