Objective: and its polymorphisms may be important in the physiopathology of obesity. We hypothesized that polymorphisms in gene may modify body mass index (BMI).
Methods: Thus, we systematically screened 4 tagging polymorphisms (rs4730153, rs2058540, rs3801267 and rs16872158) in gene and evaluated the association between the genetic variants and BMI in a population-based study including 442 subjects in northern China.
Results: We found that the SNP rs3801267 was significantly associated with decreased BMI ( = 0.026 in additive model), while the other 2 SNPs (rs4730153 and rs16872158) showed a borderline significant association with decreased BMI ( = 0.068 and 0.060 in additive models). Combined analysis of these 3 SNPs showed a significant allele-dosage association between the number of variant alleles and decreased BMI ( = 0.007).
Conclusions: These findings indicate that genetic variants in gene may modify individual BMI in the Chinese population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963396 | PMC |
| http://dx.doi.org/10.1016/j.mgene.2015.08.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of laparoscopic cholecystectomy on plasma levels of EETs, arachidonic acids derived lipid mediators.
Postgrad Med J
January 2025
Department of Medical Biochemistry, Faculty of Medicine, Niğde Omer Halisdemir University, Niğde, 51000, Turkey.
Background: Epoxyeicosatrienoic acids (EETs) are closely associated with lipoprotein metabolism, and changes in lipid profiles potentially affect their levels and functions. Given the alterations in lipid metabolism after cholecystectomy, this study aimed to investigate the levels of four EET regioisomers (free and esterified) and lipid profiles in patients with cholelithiasis after laparoscopic cholecystectomy (LC) and explore correlations between these parameters.
Methods: This prospective study involved 40 patients with symptomatic cholelithiasis who underwent LC.
Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study.
Front Endocrinol (Lausanne)
January 2025
Department of Endocrinology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, Jiangsu, China.
Background: Dyslipidemia is closely related to diabetic neuropathy. This study examined the potential causal relationship involving 179 lipid species and the disease.
Methods: The pooled data on 179 lipid species and diabetic neuropathy were obtained from previous genome-wide association studies (GWAS).
Assessing the stability of psychobiological stress reactivity during adolescence: mixed-effect modelling of cortisol responses to laboratory stressors.
HRB Open Res
January 2025
Department of Biobehavioral Health, The Pennsylvania State University - University Park Campus, University Park, Pennsylvania, PA 16802, USA.
Background: Puberty has been historically considered as a time of risk and vulnerability for young people. It is associated with rapid development in the hypothalamus, which is central in the production of both stress and sex steroids. While patterns of stress reactivity are calibrated in early life, this time of rapid development may provide a means for these patterns to change.
View Article and Find Full Text PDFPreoperative Evaluation of Oswestry Disability Index in Lumbar Spinal Stenosis: New Evidence of Time Independence of Variation Up to 1 Year.
Int J Spine Surg
January 2025
Natural Resources Institute Finland, Natural Resources, Joensuu, Finland.
Background: The Oswestry Disability Index (ODI) is a well-validated and widely used patient-reported outcome instrument to evaluate lumbar spinal stenosis (LSS) patients' treatment outcomes. The objective of the present study was to determine long the average interval between 2 preoperative measurements can be before a clinically significant difference of 10 points or more might appear.
Methods: This was a retrospective observational study utilizing prospectively collected data from a single university hospital database, which was compatible with the national registry.
A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation.
Biochem Pharmacol
January 2025
Colorectal cancer (CRC), one of the diseases posing a threat to global health, according to the latest data, is the third most common cancer globally and the second leading cause of cancer-related deaths. The development and refinement of novel structures of small molecular compounds play a crucial role in tumor treatment and overcoming drug resistance. In this study, our objective was to screen and characterize novel compounds for overcoming drug resistance via the B Lymphoma Mo-MLV insertion region 1 (Bmi-1) reporter screen assay.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!