AI Article Synopsis
- The perception of follicle-stimulating hormone (FSH) is shifting from solely a reproductive role to having impacts on other body systems.
- FSH receptors are found in various tissues outside of the reproductive system, indicating that FSH affects more than just reproduction.
- Studies suggest that high levels of serum FSH may be linked to issues like bone loss, obesity, and increased risks for cardiovascular diseases and cancer.
Article Abstract
The traditional view of folliclestimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433784 | PMC |
| http://dx.doi.org/10.3389/fendo.2019.00136 | DOI Listing |
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