Background: This study tested the hypotheses that (i) the relationship between a history of childhood abuse and severity of psychosis is mediated by loneliness; (ii) the relationship between loneliness and psychosis is mediated by within-person fluctuations in depressive and anxious feelings.
Methods: Fifty-nine individuals with non-affective psychotic disorder rated the intensity of loneliness, positive symptoms, and depressive and anxious feelings during repeated moments in daily life (Experience Sampling Method). Childhood abuse was assessed retrospectively using the 'Childhood Experience of Care and Abuse' interview. To test the mediation hypotheses, a multilevel structural equation modeling paradigm was used.
Results: As predicted, the relationship between severity of childhood abuse and positive symptoms was mediated by loneliness (b=0.08, 95% CI [0.02, 0.13], p=0.005). In turn, the relationship between loneliness and positive symptoms was mediated by within-person fluctuations in both depressive (b=0.04, 95% CI [0.02, 0.06], p<0.001) and anxious (b=0.02, 95% CI [0.01, 0.03], p=0.002) symptomatology. Depression was a stronger mediator than anxiety (b=0.02, 95% CI [0.00, 0.04], p=0.027).
Conclusions: Our findings highlight the role of childhood abuse and loneliness in the severity of psychosis in daily life.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.schres.2019.03.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Beyond the Score: Exploring the Associations Between Adverse Childhood Experiences and Electrophysiological Responses to Errors.
Stress Health
February 2025
Psychology Department, Mount St. Vincent University, Halifax, Canada.
Adverse childhood experiences (ACEs) have diverse effects on physical development and mental health. This study aimed to clarify the relationship between the quantity of ACE exposure, type of ACE exposure, and subjective level of stress felt, correlated with event-related potential activity across the scalp, while controlling for relevant confounding variables. Fifty-three participants aged 18-32 years completed questionnaires assessing their current mental health, self-regulation, childhood socioeconomic status, and history of traumatic events.
View Article and Find Full Text PDFIdentification of Behavioral, Clinical, and Psychological Antecedents of Acute Stimulant Poisoning: Development and Implementation of a Mixed Methods Psychological Autopsy Study.
JMIR Form Res
January 2025
Center on Substance Use and Health, San Francisco Department of Public Health, San Francisco, CA, United States.
Background: Despite increasing fatal stimulant poisoning in the United States, little is understood about the mechanism of death. The psychological autopsy (PA) has long been used to distinguish the manner of death in equivocal cases, including opioid overdose, but has not been used to explicitly explore stimulant mortality.
Objective: We aimed to develop and implement a large PA study to identify antecedents of fatal stimulant poisoning, seeking to maximize data gathering and ethical interactions during the collateral interviews.
The moderating effect of recent positive and negative life events on the impact of early life stress on mental wellbeing and distress.
J Psychiatr Res
December 2024
Centre for Wellbeing, Resilience and Recovery, Neuroscience Research Australia, Sydney, NSW, Australia; School of Psychology, University of New South Wales, Sydney, NSW, Australia; The Black Dog Institute, Sydney, NSW, Australia. Electronic address:
Early life stress (ELS) significantly influences mental health in later stages of life. Yet it is unclear whether recent life events lessen or intensify the effects of ELS on present wellbeing and distress. We addressed this question in 1064 healthy community adults with a normative range of wellbeing and distress.
View Article and Find Full Text PDFDemographic and clinical predictors of response and remission in the treatment of major depressive disorder with ketamine and esketamine: A systematic review.
Psychiatry Res
January 2025
Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands.
Accumulating evidence supports the efficacy of (es)ketamine in the treatment of major depressive disorder (MDD), particularly treatment-resistant depression (TRD). Yet around 50% of the individuals with TRD do not respond to (es)ketamine. Elucidating predictors of response and remission could improve treatment outcomes at the individual level by defining subpopulations that are most likely to benefit from (es)ketamine.
View Article and Find Full Text PDFRelationship between childhood abuse and self-harm among transvestites and transgender women in Rio de Janeiro state 2019-2020.
Epidemiol Serv Saude
January 2025
Universidade Federal Fluminense, Departamento de Enfermagem, Rio das Ostras, RJ, Brasil.
Objective: To analyze the relationship between childhood abuse and self-harm in a group of transvestites and transgender women from the state of Rio de Janeiro.
Methods: This was a cross-sectional study conducted with 139 participants selected through convenience sampling between 2019 and 2020. A structured questionnaire was used for data collection.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!