AI Article Synopsis
- The study presents a seven-step process for creating a DNA-encoded macrocycle library (DEML) that emphasizes diverse molecular structures inspired by natural products.
- It highlights the trade-off between achieving chemical diversity and the custom synthesis required for bifunctional building blocks.
- The research underscores the need for improved DNA synthesis techniques to enhance the design of DNA-encoded libraries.
Article Abstract
Here we show a seven-step chemical synthesis of a DNA-encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide-polyketide natural products, the library was designed to incorporate rich backbone diversity. Achieving this diversity, however, comes at the cost of the custom synthesis of bifunctional building block libraries. This study outlines the importance of careful retrosynthetic design in DNA-encoded libraries, while revealing areas where new DNA synthetic methods are needed.
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| http://dx.doi.org/10.1002/anie.201902513 | DOI Listing |
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