The author names in the original version of this article were inadvertently interchange. Correct presentation of author names is reflected here.
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http://dx.doi.org/10.1007/s00784-019-02882-4 | DOI Listing |
Cell Death Differ
January 2025
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Clinical treatment options for triple-negative breast cancer (TNBC) are currently limited to chemotherapy because of a lack of effective therapeutic targets. Recent evidence suggests that long noncoding RNAs (lncRNAs) encode bioactive peptides or proteins, thereby playing noncanonical yet significant roles in regulating cellular processes. However, the potential of lncRNA-translated products in cancer progression remains largely unknown.
View Article and Find Full Text PDFSci Rep
January 2025
State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization, Baotou Research Institute of Rare Earths, Baotou, 014030, China.
This study introduces a deep learning-based automatic evaluation method for analyzing the microstructure of steel with scanning electron microscopy (SEM), aiming to address the limitations of manual marking and subjective assessments by researchers. By leveraging advanced computer vision algorithms, specifically a suitable model for long-term dendritic solidifications named Tang Rui Detect (TRD), the method achieves efficient and accurate detection and quantification of microstructure features. This approach not only enhances the training process but also simplifies loss function design, ultimately leading to a proper evaluation of surface modifications in steel materials.
View Article and Find Full Text PDFSci Rep
January 2025
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep
January 2025
School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, 510006, China.
Multi-objective and multi-stage decision-making problems require balancing multiple objectives at each stage and making optimal decision in multi-dimensional control variables, where the commonly used intelligent optimization algorithms suffer from low solving efficiency. To this end, this paper proposes an efficient algorithm named non-dominated sorting dynamic programming (NSDP), which incorporates non-dominated sorting into the traditional dynamic programming method. To improve the solving efficiency and solution diversity, two fast non-dominated sorting methods and a dynamic-crowding-distance based elitism strategy are integrated into the NSDP algorithm.
View Article and Find Full Text PDFJ Control Release
January 2025
Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 430074 Wuhan, PR China; Shenzhen Key Laboratory of Viral Vectors for Biomedicine, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, PR China; Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, 430071 Wuhan, PR China; Key Laboratory of Quality Control Technology for Virus-Based Therapeutics, Guangdong Provincial Medical Products Administration, NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal Products, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, PR China; University of Chinese Academy of Sciences, 100049 Beijing, PR China; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 200031 Shanghai, PR China. Electronic address:
The blood-brain barrier (BBB) is a formidable barrier that restricts the entry of substances into the brain, complicating the study of brain function and the treatment of neurological conditions. Traditional methods of delivering genes from the periphery to the central nervous system (CNS) using adeno-associated viruses (AAVs) often require high doses, which can trigger immune responses and hepatotoxicity. Here, we developed a new AAV variant named AAVhu.
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