Introduction: Few studies have examined maternal intentions and practices related to interpregnancy interval (IPI). IPI less than 18 months has been linked to increased preterm birth and infant mortality. This manuscript reports on a cross-sectional survey of mothers conducted to understand maternal knowledge, attitudes, and practice of IPI in Sedgwick County, Kansas.
Methods: New and expectant mothers and mothers of neonatal infant care unit (NICU) graduates (n = 125) were surveyed regarding the issues surrounding IPI. Front desk staff handed out self-administered surveys, which were returned to a nurse upon completion. NICU participants were emailed a link to the survey hosted on SurveyMonkey.
Results: Fewer than 30% of mothers reported previously receiving information about IPI from any source. When asked about risks associated with IPI, women frequently (n = 58, 45%) identified increased risk for birth outcomes with no known association with short IPI. Findings regarding maternal attitudes surrounding optimal IPI were mixed with many mothers defining ideal IPI as less than 18 months (n = 52, 42%), while broadly reporting they believed that a woman's body needs time to heal between pregnancies. Respondents from the NICU sample generally reported shorter optimal IPI values than the other participants. When IPI was estimated from participants' past pregnancies, half of IPIs were less than 18 months. Mothers reported they favored healthcare providers as a source for IPI education. Face-to-face discussions or printed materials were the preferred modes of education.
Conclusions: Women were aware of the need for spacing between pregnancies, however, that knowledge was unassociated with past behavior. These findings should be taken into consideration when formulating future interventions.
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Front Transplant
December 2024
Duke Transplant Center, Duke University School of Medicine, Durham, NC, United States.
Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is one of the leading causes of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR, however PI-associated toxicity limits their therapeutic utility. Novel immunoproteasome inhibitors (IPIs) have higher specificity for immune cells and have not been investigated for AMR in cardiac transplant patients.
View Article and Find Full Text PDFParasit Vectors
December 2024
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
Background: Intestinal parasitic infections (IPIs) are a major health problem among the Karen hill tribe in Thailand. This study aimed to evaluate the effect of an integrated intervention program of drug therapy combined with water, sanitation, and hygiene (WASH) education on reinfection with IPIs among the Karen hill tribe in an endemic area of northern Thailand.
Methods: A quasi-experimental study was conducted in two Karen villages, involving 691 residents, in Omkoi District, Chiang Mai Province; one village was designated as the intervention group and the other as the control group.
BMC Complement Med Ther
December 2024
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: A precise observation is that the cervix's solid tumors possess hypoxic regions where the oxygen concentration drops below 1.5%. Hypoxia negatively impacts the host's immune system and significantly diminishes the effectiveness of several treatments, including radiotherapy and chemotherapy.
View Article and Find Full Text PDFInt J Pediatr Otorhinolaryngol
December 2024
Hacettepe University, Faculty of Medicine, Department of Opthalmology, Ankara, Turkey.
Aims And Objectives: This study aimed to investigate the presence, type, and severity of hearing losses in individuals with Duane Retraction Syndrome (DRS), and to ascertain if there are anomalies in the auditory pathways at the brainstem level in DRS, believed to arise from aberrant interaction between cranial nerves and brainstem nuclei.
Study Design: Cross-sectional observational study.
Setting: Tertiary referral centre.
Leuk Res
December 2024
Ankara Yıldırım Beyazıt University, Hematology Clinic, Ankara, Turkey.
CD47 interacts with signal regulatory protein alpha (SIRPα) on macrophages to deliver an anti-phagocytic signal, enabling tumor cells to evade immune destruction. This study explores the relationship between CD47 and SIRPα expression and key clinical prognostic factors, microvascular density (MVD), and tumor-infiltrating lymphocytes (TIL) in Diffuse Large B Cell Lymphoma (DLBCL) cases. We analyzed tissue samples from 122 DLBCL cases using tissue microarray (TMA) blocks and immunohistochemical staining for CD47, SIRPα, CD31, and CD3.
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