Dengue is one of the most common flavivirus infections which can manifest from common flu-like fever to fatal hemorrhagic complication. Epidemics of dengue return every year with peaks during the rainfall claiming substantial number of lives in the tropical and subtropical regions of the world. We present manifestations of dengue in patients who underwent neurosurgery in a tertiary referral center during such an epidemic. There were total four patients referred for neurosurgical intervention as sequelae to dengue coagulopathy. Among them, three had intracranial bleeds and one had spinal cord hematoma along with intracranial hemorrhages. This small series includes the youngest reported case of dengue coagulopathy with intracranial bleed and only the second case of spontaneous intraspinal hematoma sequelae to dengue hemorrhagic fever. The situations where patients contract dengue in a setting of neurosurgical intervention are grave. The margin of safety in the presence of dengue coagulopathy is narrow. The surgeon has to outweigh benefit against risk of surgery in each individual.
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http://dx.doi.org/10.4103/ajns.AJNS_318_17 | DOI Listing |
Trop Doct
January 2025
Consultant Intensivist, Department of Intensive Care, Yashoda Hospitals, Somajiguda, Hyderabad, Telangana, India.
Dengue infection is emerging as one of the most common tropical diseases globally. It manifests in varying severity from asymptomatic to the most severe forms of the disease, characterized by coagulopathy, increased vascular fragility, and permeability (dengue haemorrhagic fever) that may progress to hypovolaemic shock (dengue shock syndrome). For atypical manifestations, a new terminology known as expanded dengue syndrome (EDS) was introduced.
View Article and Find Full Text PDFCureus
October 2024
Internal Medicine, Max Smart Super Speciality Hospital, New Delhi, IND.
J Virol
December 2024
CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India.
Unlabelled: Dengue virus NS1 protein is a major pathogenic protein. In this study, we examined the role of NS1 in coagulopathy associated with Dengue infection, a common feature of Dengue virus pathogenesis. Since most coagulation factors are produced by hepatocytes and liver is key organ affected during infection, we conducted transcriptomics using total-RNA extracted from Huh7 cells overexpressing NS1 protein.
View Article and Find Full Text PDFTravel Med Infect Dis
September 2024
Facultad de Medicina, Universidad Militar Nueva Granada, Bogotá D.C, Colombia; Servicio de Infectología, Hospital Militar Central, Bogotá D.C, Colombia; Servicios y Asesorías en Infectología - SAI, Bogotá D.C, Colombia. Electronic address:
Viruses
July 2024
Department of Haematology Oncology, National University Cancer Institute, National University Health System, Singapore 119228, Singapore.
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