Zinc Acetate Potentiates the Action of Tosufloxacin against Escherichia coli Biofilm Persisters.

Antimicrob Agents Chemother

Institut Pasteur, Genetics of Biofilm Unit, Department of Microbiology, Paris, France

Published: June 2019

Formation of bacterial biofilms is a major health threat due to their high levels of tolerance to multiple antibiotics and the presence of persisters responsible for infection relapses. We previously showed that a combination of starvation and induction of SOS response in biofilm led to increased levels of persisters and biofilm tolerance to fluoroquinolones. In this study, we hypothesized that inhibition of the SOS response may be an effective strategy to target biofilms and fluoroquinolone persister cells. We tested the survival of biofilms to different classes of antibiotics in starved and nonstarved conditions and in the presence of zinc acetate, a SOS response inhibitor. We showed that zinc acetate potentiates, albeit moderately, the activity of fluoroquinolones against persisters in starved biofilms. The efficacy of zinc acetate to increase fluoroquinolone activity, particularly that of tosufloxacin, suggests that such a combination may be a potential strategy for treating biofilm-related bacterial infections.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535537PMC
http://dx.doi.org/10.1128/AAC.00069-19DOI Listing

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