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Horizontal transfer and recombination fuel Ty4 retrotransposon evolution in Saccharomyces.
Genome Biol Evol
January 2025
Institute of Bioinformatics, University of Georgia, 120 E. Green St., Athens, GA, USA.
Horizontal transposon transfer (HTT) plays an important role in the evolution of eukaryotic genomes, however the detailed evolutionary history and impact of most HTT events remain to be elucidated. To better understand the process of HTT in closely related microbial eukaryotes, we studied Ty4 retrotransposon subfamily content and sequence evolution across the genus Saccharomyces using short- and long-read whole genome sequence data, including new PacBio genome assemblies for two S. mikatae strains.
View Article and Find Full Text PDFBackground: Gut microbiome features have been linked with many diseases including Alzheimer's disease (AD). Evidence suggests that the gut microbiota may impact cognition of AD patients. We explored the association of gut microbiota and three PACC3 cognitive scores in individuals at risk for AD.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: Emerging evidence underscores the significant influence of diet on risk for Alzheimer's disease and related dementias (ADRD). In particular, a Western dietary pattern associates with increased risk for ADRD, with proposed mediation via inflammatory mechanisms, among others. Although a Western dietary pattern associates with gut microbiome alterations, it remains unclear whether microbial alterations mediate Western diet-associated inflammation and neurodegeneration.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: Heavy alcohol consumption is associated with increased risk for Alzheimer's disease and related dementias (ADRD), with mixed evidence suggesting a dose-dependent nonlinear effect of alcohol on ADRD. Potential mechanisms by which alcohol may promote or attenuate brain pathology need further exploration. Although chronic alcohol consumption associates with gut microbiome alterations, it remains unclear whether microbial alterations mediate alcohol-associated neurodegeneration and cognitive decline.
View Article and Find Full Text PDFBackground: Gut microbiome features are known to be different in Alzheimer's disease (AD) patients compared with cognitively normal. Evidence suggests that the gut microbiota may be related to the pathology of AD. We examined the association between the gut microbiome and AD phenotypes and genotypes.
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