GHRH was isolated from two GHRH-secreting pancreatic tumors which resulted in clinical acromegaly. Over 98% of acromegalic patients have a pituitary adenoma; however, acromegaly may occasionally result from ectopic or eutopic GHRH secretion. Administration of GHRH to normal adults stimulates growth hormone (GH) secretion; it may also stimulate GH release in some adults with GH deficiency in childhood and in a majority of GH-deficient children. Continuous infusion of GHRH to normal men stimulates GH secretion which augments naturally occurring GH pulses. GHRH is effective when administered subcutaneously and intranasally, but requires 30- and 300-fold higher doses, respectively. Intermittent subcutaneous GHRH therapy promotes acceleration of linear growth in GH-deficient children and appears promising as a treatment for these children.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000180547 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
GHRH and the prostate.
Rev Endocr Metab Disord
November 2024
Departamento de Biología de Sistemas. Unidad de Bioquímica y Biología Molecular (Research group "Cánceres de origen epitelial"), Universidad de Alcalá, Campus Científico-Tecnológico, 28871, Alcalá de Henares, Madrid, Spain.
Article Synopsis
- In the late 1960s and early 1970s, researchers isolated and studied hypothalamic regulatory hormones, discovering both normal and tumor tissues can produce growth hormone-releasing hormone (GHRH).
- GHRH receptors, particularly the pituitary-type (pGHRH-R), are predominantly found in the anterior pituitary but also in other body cells and various cancers, including prostate cancer, with splice variants detected in these tissues.
- GHRH activates multiple signaling pathways that promote cell survival and proliferation, making GHRH receptors potential drug targets, especially in prostate conditions, with recent antagonists showing enhanced anticancer and anti-inflammatory effects.
Growth hormone-releasing hormone and cancer.
Rev Endocr Metab Disord
October 2024
Department of Medical Sciences, University of Turin, Turin, Italy.
The hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of growth hormone (GH), stimulates the proliferation of human normal and malignant cells by binding to GHRH-receptor (GHRH-R) and its main splice variant, SV1. Both GHRH and GHRH-Rs are expressed in various cancers, forming a stimulatory pathway for cancer cell growth; additionally, SV1 possesses ligand independent proliferative effects. Therefore, targeting GHRH-Rs pharmacologically has been proposed for the treatment of cancer.
View Article and Find Full Text PDFBone Quality Indices Correlate with Growth Hormone Secretory Capacity in Women Affected by Weight Excess: A Cross-Sectional Study.
J Clin Med
August 2024
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Obesity can be associated with impaired growth hormone (GH) secretion, with possible negative repercussions on bone health. We aimed to investigate the relationships between GH secretory capacity, evaluated with GHRH + arginine stimulation test, and bone parameters, assessed with a dual-energy X-ray absorptiometer, in a population of adult female patients affected by overweight and obesity. : We assessed 276 women affected by overweight or obesity referred to the High-Specialization Center for the Care of Obesity, Umberto I Polyclinic, between 2014 and 2019 with signs or symptoms of growth hormone deficiency (GHD).
View Article and Find Full Text PDFThe allostery and modification of hGHRH molecules and specific dimer produced significant fertility effect by proliferating and activating in-situ ovarian mesenchymal stem cells.
Eur J Pharm Sci
June 2024
Department of Clinical Laboratories & Pathology, Guangdong Provincial Cops Hospital of Chinese People's Armed Police Forces, Guangzhou 510507, China.
Article Synopsis
- The study investigates how the interaction between growth hormone receptors impacts cell repair and fertility in hamster infertility models.
- Grinodin and 2Y were tested, showing Grinodin resulted in significantly higher birth rates compared to human menopausal gonadotropin (hMG) and human growth hormone (hGH).
- Grinodin promoted the growth of ovarian stem cells and follicles while reducing negative hormonal effects, suggesting its potential as a more effective treatment for fertility than 2Y, hMG, or hGH.
Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency.
J Endocrinol Invest
November 2024
Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil.
Purpose: Individuals with isolated GH deficiency (IGHD) due to a mutation in the GHRH receptor gene have a normal life expectancy and above 50 years of age, similar total cognitive performance, with better attention and executive function than controls. Our objectives were to evaluate their brain morphometry and brain aging using MRI.
Methods: Thirteen IGHD and 14 controls matched by age, sex, and education, were enrolled.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!