To determine the effects of short-term Montmorency cherry (MC) supplementation upon exercise performance, total blood nitrate levels, muscle oxygenation, and slow-component [Formula: see text]O kinetics. Twelve healthy male participants ingested a MC or placebo (PL) supplement in a randomized cross-over fashion over a six day period then cycled at a power output achieved at 70% of [Formula: see text]O peak for a maximum of 30 minutes or until exhaustion. Near-Infrared Spectroscopy sensors were used to determine muscle oxygenation. Blood was collected one hour post-supplement consumption on day one, day six, and one hour post-exercise. All results are presented as mean ± SEM. Blood nitrate (μM/L) levels were not different one hour post-ingestion (MC = 8.30 ± 2.15, PL = 8.18 ± 1.86), following six days of supplementation (MC = 9.14 ± 1.89, PL = 7.24 ± 1.75) or one hour post-exercise (MC = 9.63 ± 1.61, PL = 7.97 ± 1.92) for treatment F = 0.26, p = 0.62; for time F = 0.45, p = 0.64; or treatment by time interaction F = 2.28, p = 0.13. Muscle oxygenation was not different between treatments for the right or left vastus lateralis, F = 0.68, p = 0.81 nor was time to respiratory compensation point (minutes) (MC = 18.40 ± 1.48, PL = 17.16 ± 1.78) F = 0.52, p = 0.60. MC supplement ingestion does not alter blood nitrate levels. Short-term MC ingestion does not increase muscle oxygenation during cycling exercise nor does it change slow-component [Formula: see text]O kinetics.
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http://dx.doi.org/10.1024/0300-9831/a000575 | DOI Listing |
JAMA Cardiol
March 2025
Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.
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J Cereb Blood Flow Metab
March 2025
Department of Cell Biology and Physiology, Curriculum in Neuroscience, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Collateral blood vessels are unique, naturally occurring endogenous bypass vessels that provide alternative pathways for oxygen delivery in obstructive arterial conditions and diseases. Surprisingly however, the capacity of the collateral circulation to provide protection varies greatly among individuals, resulting in a significant fraction having poor collateral circulation in their tissues. We recently reviewed evidence that the presence of naturally-occurring polymorphisms in genes that determine the number and diameter of collaterals that form during development (ie, genetic background), is a major contributor to this variation.
View Article and Find Full Text PDFHCA Healthc J Med
February 2025
Ross University School of Medicine, Barbados.
Background: Airway management in emergency situations poses significant challenges, particularly in patients with difficult airway anatomy or comorbid conditions. Blind nasal intubation has been explored as a rescue technique when conventional methods fail. Masseter muscle rigidity (MMR), characterized by significant jaw muscle stiffness, is a recognized complication following succinylcholine administration that can complicate traditional approaches to securing an airway.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Department of Pathology, Indira Gandhi Medical College and Research Institute, Puducherry, India.
Thyroid cancer remains one of the leading endocrine malignancies with Conventional Papillary Thyroid Carcinoma (CVPTC) being the most commonly reported cancer. Caseating granulomatous inflammation is an unusual presentation in the thyroid even in places with high incidence of tuberculosis. The association of CVPTC with caseating granulomatous inflammation is infrequent.
View Article and Find Full Text PDFFront Med (Lausanne)
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Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Background: Cipepofol is a highly selective gamma-aminobutyric acid A receptor potentiator. As a new sedative drug, detailed studies on its respiratory effects are further needed. The present study aims to investigate the effects of cipepofol on breathing patterns, respiratory drive, and inspiratory effort in mechanically ventilated patients.
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