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CPAP Titration Pressure in Split-Night, Full-Night, and Home Auto-Titration: A Prospective Comparative Analysis of Patients With Moderate to Severe Obstructive Sleep Apnea.
Nat Sci Sleep
March 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Purpose: This prospective study aimed to compare titration pressures obtained using three methods-full-night titration (FN-T), split-night titration (SN-T), and home auto-titration (HA-T)- in patients with moderate to severe obstructive sleep apnea (OSA). Additionally, factors contributing to pressure differences relative to FN-T were investigated.
Methods: SN-T was performed on 74 patients suspected of having OSA.
Avoiding Invasive Measures: Sphenopalatine Ganglion Block as a Substitute for Epidural Blood Patch in Post-dural Puncture Headache: A Case Report.
Anesth Pain Med
August 2024
Associate Professor of Anesthesiology,Department of Anesthesiology, School of Medicine Birjand University of Medical Sciences.
Introduction: Post-dural puncture headache (PDPH) is a well-known consequence of neuraxial anesthesia that can impede patient recovery and delay early discharge. Traditional remedies include hydration and the administration of simple analgesics for symptom relief. When symptoms persist despite conservative interventions, an epidural blood patch (EBP) is typically recommended.
View Article and Find Full Text PDFSpectroscopic Characterization Using H and C Nuclear Magnetic Resonance and Computational Analysis of the Complex of Donepezil with 2,6-Methyl-β-Cyclodextrin and Hydroxy Propyl Methyl Cellulose.
Molecules
March 2025
Department of Chemistry, National and Kapodistrian University of Athens, Zografou, 15771 Athens, Greece.
Donepezil (DH), a selective acetylcholinesterase inhibitor, is widely used to manage symptoms of mild to moderate Alzheimer's disease by enhancing cholinergic neurotransmission and preventing acetylcholine breakdown. Despite the effectiveness of oral formulations, extensive hepatic metabolism and low systemic bioavailability have driven the search for alternative delivery systems. This study focuses on nasal delivery as a non-parenteral substitute, utilizing hydroxypropyl methylcellulose (HPMC) for its mucoadhesive properties and methyl-β-cyclodextrin (Me-β-CD) for its ability to enhance permeability and form inclusion complexes with drugs.
View Article and Find Full Text PDFBlind Nasal Intubation as a Rescue Strategy in Difficult Airway Management.
HCA Healthc J Med
February 2025
Ross University School of Medicine, Barbados.
Background: Airway management in emergency situations poses significant challenges, particularly in patients with difficult airway anatomy or comorbid conditions. Blind nasal intubation has been explored as a rescue technique when conventional methods fail. Masseter muscle rigidity (MMR), characterized by significant jaw muscle stiffness, is a recognized complication following succinylcholine administration that can complicate traditional approaches to securing an airway.
View Article and Find Full Text PDFComparing Nasal Splints and Quilting Sutures in Septoplasty: A Systematic Review and Meta-analysis.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Otolaryngology-Head and Neck Surgery, King Abdulaziz University Hospital, King Saud University, King Khaled Road, Riyadh, 11223 Saudi Arabia.
Background: Nasal packing post-septoplasty often leads to discomfort, breathing difficulties, and elevated infection risk. Alternative methods, such as intranasal splinting and quilting sutures, have been proposed to mitigate these issues. This study evaluates their effectiveness in reducing postoperative pain and complications.
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