Putting one's feelings into words (also called affect labeling) can attenuate positive and negative emotions. Here, we track the evolution of specific emotions for 74,487 Twitter users by analysing the emotional content of their tweets before and after they explicitly report experiencing a positive or negative emotion. Our results describe the evolution of emotions and their expression at the temporal resolution of one minute. The expression of positive emotions is preceded by a short, steep increase in positive valence and followed by short decay to normal levels. Negative emotions, however, build up more slowly and are followed by a sharp reversal to previous levels, consistent with previous studies demonstrating the attenuating effects of affect labeling. We estimate that positive and negative emotions last approximately 1.25 and 1.5 h, respectively, from onset to evanescence. A separate analysis for male and female individuals suggests the potential for gender-specific differences in emotional dynamics.
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http://dx.doi.org/10.1038/s41562-018-0490-5 | DOI Listing |
ESMO Open
January 2025
Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Oncode Institute, Utrecht, The Netherlands. Electronic address:
Background: Many patients with cancer exhibit primary or rapid secondary resistance to targeted therapy (TT). We hypothesized that a higher number of altered oncogenic signaling pathways [pathway alteration load (PAL)] would reduce the benefit of TT which only intervenes in one pathway. This hypothesis was tested in the Drug Rediscovery Protocol (DRUP).
View Article and Find Full Text PDFEquine Vet J
January 2025
University of Liverpool, Institute of Life Course and Medical Sciences, William Henry Duncan Building, Liverpool, UK.
Background: Equine dental diseases significantly impact a horse's overall health, performance and quality of life. They can result in secondary infections and digestive disturbances, potentially leading to colic. A recently described disease affecting the incisors of horses is equine odontoclastic tooth resorption and hypercementosis (EOTRH).
View Article and Find Full Text PDFJ Neurol
January 2025
IRCCS Stella Maris Foundation, Via Dei Giacinti 2, 56128, Pisa, Italy.
The neuronal ceroid lipofuscinoses (NCLs) are incurable pediatric neurodegenerative diseases characterized by accumulation of lysosomal material and dysregulation of autophagy. Given the promising results of treatment with trehalose, an autophagy inducer, in cell and animal models of NCL, we conducted an open-label, non-placebo-controlled, non-randomized 12-month prospective study in NCL patients receiving oral trehalose (4 g/day). All were treated with a commercially available formulation for 6 months, followed by a 6-month washout.
View Article and Find Full Text PDFLab Chip
January 2025
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Nucleic acid testing (NAT) is widely considered the gold standard in analytical fields, with applications spanning environmental monitoring, forensic science and clinical diagnostics, among others. However, its widespread use is often constrained by complicated assay procedures, the need for specialized equipment, and the complexity of reagent handling. In this study, we demonstrate a fully integrated 3D-printed biosensensing device employing a CRISPR/Cas12a-based dual-enzymatic mechanism for highly sensitive and user-friendly nucleic acid detection.
View Article and Find Full Text PDFBackground: Chronic inflammation has been linked to many psychiatric disorders, and therefore, pertinent anti-inflammatory therapies have been empirically evaluated for management. An enduring example of long-term safety, attainability, and versatility has been pentoxifylline (PTX). PTX is a phosphodiesterase inhibitor that modulates inflammatory mediators and affects most blood components and the blood vessels.
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